MicroRNA deregulation and cancer and medicinal plants as microRNA regulator
MircroRNAs (miRNAs) are short non-coding RNAs with a length of approximately 20-22 nucleotides, which interact with their target mRNAs at 3’-untranslated region by partial pairing. The miRNA- mRNA interaction leads to induction of mRNA degradation and eventually translational inhibition. Thus, miRNA...
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Wolters Kluwer Medknow Publications
2020-01-01
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doaj-c94a9d3f5d7d427fb7e74d707a729cfa2020-11-25T01:12:28ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2588-92222020-01-01102475310.4103/2221-1691.275419MicroRNA deregulation and cancer and medicinal plants as microRNA regulatorNathan ShanmugapriyaSreenivasan SasidharanMircroRNAs (miRNAs) are short non-coding RNAs with a length of approximately 20-22 nucleotides, which interact with their target mRNAs at 3’-untranslated region by partial pairing. The miRNA- mRNA interaction leads to induction of mRNA degradation and eventually translational inhibition. Thus, miRNAs play an important role in virtually all cellular processes, especially differentiation, proliferation, migration, and apoptosis. The deregulation of miRNAs may lead to serious diseases including cancer. There is mounting evidence demonstrating the participation of miRNA regulation during carcinogenesis. In this review, we discuss an updated miRNA biogenesis, mechanisms involved in their deregulation, and their role in cancer development. This review also summarizes updated information on potential medicinal plants which regulate miRNA expression as a promising molecular miRNA therapeutic approach for cancers.http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=2;spage=47;epage=53;aulast=Shanmugapriyamirna; biogenesis; cancer; medicinal plants |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nathan Shanmugapriya Sreenivasan Sasidharan |
spellingShingle |
Nathan Shanmugapriya Sreenivasan Sasidharan MicroRNA deregulation and cancer and medicinal plants as microRNA regulator Asian Pacific Journal of Tropical Biomedicine mirna; biogenesis; cancer; medicinal plants |
author_facet |
Nathan Shanmugapriya Sreenivasan Sasidharan |
author_sort |
Nathan Shanmugapriya |
title |
MicroRNA deregulation and cancer and medicinal plants as microRNA regulator |
title_short |
MicroRNA deregulation and cancer and medicinal plants as microRNA regulator |
title_full |
MicroRNA deregulation and cancer and medicinal plants as microRNA regulator |
title_fullStr |
MicroRNA deregulation and cancer and medicinal plants as microRNA regulator |
title_full_unstemmed |
MicroRNA deregulation and cancer and medicinal plants as microRNA regulator |
title_sort |
microrna deregulation and cancer and medicinal plants as microrna regulator |
publisher |
Wolters Kluwer Medknow Publications |
series |
Asian Pacific Journal of Tropical Biomedicine |
issn |
2588-9222 |
publishDate |
2020-01-01 |
description |
MircroRNAs (miRNAs) are short non-coding RNAs with a length of approximately 20-22 nucleotides, which interact with their target mRNAs at 3’-untranslated region by partial pairing. The miRNA- mRNA interaction leads to induction of mRNA degradation and eventually translational inhibition. Thus, miRNAs play an important role in virtually all cellular processes, especially differentiation, proliferation, migration, and apoptosis. The deregulation of miRNAs may lead to serious diseases including cancer. There is mounting evidence demonstrating the participation of miRNA regulation during carcinogenesis. In this review, we discuss an updated miRNA biogenesis, mechanisms involved in their deregulation, and their role in cancer development. This review also summarizes updated information on potential medicinal plants which regulate miRNA expression as a promising molecular miRNA therapeutic approach for cancers. |
topic |
mirna; biogenesis; cancer; medicinal plants |
url |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=2;spage=47;epage=53;aulast=Shanmugapriya |
work_keys_str_mv |
AT nathanshanmugapriya micrornaderegulationandcancerandmedicinalplantsasmicrornaregulator AT sreenivasansasidharan micrornaderegulationandcancerandmedicinalplantsasmicrornaregulator |
_version_ |
1725166111606964224 |