"Intravenous Magnesium Sulfate as an adjunct in the treatment of severe Asthmatic patients non-responding to conventional therapy "

• Main Authors: Bijani KH, Moghadamnia AA, Islami Khalili E
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2001-12-01
• Series: Acta Medica Iranica
• Subjects: Acute asthma; Non-responding; Magnesium sulfate (MgSO4); Peak expiratory flow rate (PEER)
• Online Access: https://acta.tums.ac.ir/index.php/acta/article/view/2480
• ISSN: 0044-6025; 1735-9694

Treatment of acute asthma is based on rapid reversal of bronchospasm and arresting airway inflammation. This study was done to determine the effect of intravenous MgSO4 for improvement of pulmonary fuction in patients with acute asthma non-responding to routine therapy. This randomized, double –blind controlled study was conducted on 48 patients, magnesium sulfate group , n=48 aged 12-85 years, 26 men, 22 women, and control (saline) group, n=33, aged 15-80 years, 17 men, 16 women, who had not responded to routine treatment. Peak expiratory flow rate (PEFR) was done before MgSO4 (25 mg/kg) and normal saline (100 ml) as a baseline criteria and after infusion of drugs at 30 mm and 3 hr. All patients were also given bronchodilators. The main outcome was PEER. Data were analyzed by X2 and t-test and differences between each point, were considered significant at P