Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid β protein
<p>Abstract</p> <p>Background</p> <p>The amyloid precursor protein (APP) is transported via the secretory pathway to the cell surface, where it may be cleaved within its ectodomain by α-secretase, or internalized within clathrin-coated vesicles. An alternative proteolyt...
Main Authors: | Lopez-Coviella Ignacio, Balcz Brigitte A, Carey Robyn M, Slack Barbara E |
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Format: | Article |
Language: | English |
Published: |
BMC
2005-08-01
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Series: | BMC Cell Biology |
Online Access: | http://www.biomedcentral.com/1471-2121/6/30 |
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