Replay of Learned Neural Firing Sequences during Rest in Human Motor Cortex

Summary: The offline “replay” of neural firing patterns underlying waking experience, previously observed in non-human animals, is thought to be a mechanism for memory consolidation. Here, we test for replay in the human brain by recording spiking activity from the motor cortex of two participants w...

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Main Authors:	Jean-Baptiste Eichenlaub, Beata Jarosiewicz, Jad Saab, Brian Franco, Jessica Kelemen, Eric Halgren, Leigh R. Hochberg, Sydney S. Cash
Format:	Article
Language:	English
Published:	Elsevier 2020-05-01
Series:	Cell Reports
Subjects:	memory replay learning consolidation reactivation human
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124720305301

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spelling	doaj-c95f35ef4889474ab31aacbc956865802020-11-25T03:30:28ZengElsevierCell Reports2211-12472020-05-01315Replay of Learned Neural Firing Sequences during Rest in Human Motor CortexJean-Baptiste Eichenlaub0Beata Jarosiewicz1Jad Saab2Brian Franco3Jessica Kelemen4Eric Halgren5Leigh R. Hochberg6Sydney S. Cash7Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA; Corresponding authorDepartment of Neuroscience, Brown University, Providence, RI, USA; Carney Institute for Brain Science, Brown University, Providence, RI, USA; VA RR&D Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of VA Medical Center, Providence, RI, USA; Corresponding authorCarney Institute for Brain Science, Brown University, Providence, RI, USA; VA RR&D Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of VA Medical Center, Providence, RI, USA; School of Engineering, Brown University, Providence, RI, USACenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, USACenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, USADepartments of Radiology and Neuroscience, Kavli Institute for Brain and Mind, University of California, San Diego, CA, USACenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA; Carney Institute for Brain Science, Brown University, Providence, RI, USA; VA RR&D Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of VA Medical Center, Providence, RI, USA; School of Engineering, Brown University, Providence, RI, USACenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USASummary: The offline “replay” of neural firing patterns underlying waking experience, previously observed in non-human animals, is thought to be a mechanism for memory consolidation. Here, we test for replay in the human brain by recording spiking activity from the motor cortex of two participants who had intracortical microelectrode arrays placed chronically as part of a brain-computer interface pilot clinical trial. Participants took a nap before and after playing a neurally controlled sequence-copying game that consists of many repetitions of one “repeated” sequence sparsely interleaved with varying “control” sequences. Both participants performed repeated sequences more accurately than control sequences, consistent with learning. We compare the firing rate patterns that caused the cursor movements when performing each sequence to firing rate patterns throughout both rest periods. Correlations with repeated sequences increase more from pre- to post-task rest than do correlations with control sequences, providing direct evidence of learning-related replay in the human brain.http://www.sciencedirect.com/science/article/pii/S2211124720305301memoryreplaylearningconsolidationreactivationhuman
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jean-Baptiste Eichenlaub Beata Jarosiewicz Jad Saab Brian Franco Jessica Kelemen Eric Halgren Leigh R. Hochberg Sydney S. Cash
spellingShingle	Jean-Baptiste Eichenlaub Beata Jarosiewicz Jad Saab Brian Franco Jessica Kelemen Eric Halgren Leigh R. Hochberg Sydney S. Cash Replay of Learned Neural Firing Sequences during Rest in Human Motor Cortex Cell Reports memory replay learning consolidation reactivation human
author_facet	Jean-Baptiste Eichenlaub Beata Jarosiewicz Jad Saab Brian Franco Jessica Kelemen Eric Halgren Leigh R. Hochberg Sydney S. Cash
author_sort	Jean-Baptiste Eichenlaub
title	Replay of Learned Neural Firing Sequences during Rest in Human Motor Cortex
title_short	Replay of Learned Neural Firing Sequences during Rest in Human Motor Cortex
title_full	Replay of Learned Neural Firing Sequences during Rest in Human Motor Cortex
title_fullStr	Replay of Learned Neural Firing Sequences during Rest in Human Motor Cortex
title_full_unstemmed	Replay of Learned Neural Firing Sequences during Rest in Human Motor Cortex
title_sort	replay of learned neural firing sequences during rest in human motor cortex
publisher	Elsevier
series	Cell Reports
issn	2211-1247
publishDate	2020-05-01
description	Summary: The offline “replay” of neural firing patterns underlying waking experience, previously observed in non-human animals, is thought to be a mechanism for memory consolidation. Here, we test for replay in the human brain by recording spiking activity from the motor cortex of two participants who had intracortical microelectrode arrays placed chronically as part of a brain-computer interface pilot clinical trial. Participants took a nap before and after playing a neurally controlled sequence-copying game that consists of many repetitions of one “repeated” sequence sparsely interleaved with varying “control” sequences. Both participants performed repeated sequences more accurately than control sequences, consistent with learning. We compare the firing rate patterns that caused the cursor movements when performing each sequence to firing rate patterns throughout both rest periods. Correlations with repeated sequences increase more from pre- to post-task rest than do correlations with control sequences, providing direct evidence of learning-related replay in the human brain.
topic	memory replay learning consolidation reactivation human
url	http://www.sciencedirect.com/science/article/pii/S2211124720305301
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Replay of Learned Neural Firing Sequences during Rest in Human Motor Cortex

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