Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia
Objective: to evaluate the efficiency of multimodal epidural analgesia (EA) in patients with chronic critical lower extremity ischemia (CLEI) in the preoperative period. Subjects and methods. A prospective randomized controlled study was conducted in 150 patients.According to the anesthesia mode, th...
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Russian Academy of Medical Sciences
2010-04-01
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doaj-c977ba15f80c473b8d0219feb60308982021-07-28T21:21:51ZrusRussian Academy of Medical SciencesObŝaâ Reanimatologiâ1813-97792411-71102010-04-016210.15360/1813-9779-2010-2-25461Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity IschemiaI. E. GolubA. Yu. NovikovL. V. SorokinaA. V. NeupokoevaObjective: to evaluate the efficiency of multimodal epidural analgesia (EA) in patients with chronic critical lower extremity ischemia (CLEI) in the preoperative period. Subjects and methods. A prospective randomized controlled study was conducted in 150 patients.According to the anesthesia mode, the patients were divided into 5 groups: 1) EA with a local anesthetic; 2) EA in combination with a nonsteroidal anti-inflammatory drug (ketoprophen); 3) EA in combination with ketoprophen and subnarcotic doses of ketamine; 4) EA in combination with fentanyl and ketoprophen; 5) EA in combination with fentanyl, ketoprophen, and ketamine. Results. The developed procedure for prolonged multimodal EA allows the stabilization of hemodynamics, the concentration of cortisol and metabolites (glucose, lactate), and the values of regional blood flow. Conclusion. EA with a local anesthetic in combination with fentanyl, ketoprophen, and ketamine is the most effective method for analgesia in patients with CLEI in the preoperative period. Key words: multimodal analgesia.https://www.reanimatology.com/rmt/article/view/461 |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
I. E. Golub A. Yu. Novikov L. V. Sorokina A. V. Neupokoeva |
spellingShingle |
I. E. Golub A. Yu. Novikov L. V. Sorokina A. V. Neupokoeva Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia Obŝaâ Reanimatologiâ |
author_facet |
I. E. Golub A. Yu. Novikov L. V. Sorokina A. V. Neupokoeva |
author_sort |
I. E. Golub |
title |
Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia |
title_short |
Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia |
title_full |
Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia |
title_fullStr |
Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia |
title_full_unstemmed |
Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia |
title_sort |
multimodality therapy for chronic pain syndrome in critical lower extremity ischemia |
publisher |
Russian Academy of Medical Sciences |
series |
Obŝaâ Reanimatologiâ |
issn |
1813-9779 2411-7110 |
publishDate |
2010-04-01 |
description |
Objective: to evaluate the efficiency of multimodal epidural analgesia (EA) in patients with chronic critical lower extremity ischemia (CLEI) in the preoperative period. Subjects and methods. A prospective randomized controlled study was conducted in 150 patients.According to the anesthesia mode, the patients were divided into 5 groups: 1) EA with a local anesthetic; 2) EA in combination with a nonsteroidal anti-inflammatory drug (ketoprophen); 3) EA in combination with ketoprophen and subnarcotic doses of ketamine; 4) EA in combination with fentanyl and ketoprophen; 5) EA in combination with fentanyl, ketoprophen, and ketamine. Results. The developed procedure for prolonged multimodal EA allows the stabilization of hemodynamics, the concentration of cortisol and metabolites (glucose, lactate), and the values of regional blood flow. Conclusion. EA with a local anesthetic in combination with fentanyl, ketoprophen, and ketamine is the most effective method for analgesia in patients with CLEI in the preoperative period. Key words: multimodal analgesia. |
url |
https://www.reanimatology.com/rmt/article/view/461 |
work_keys_str_mv |
AT iegolub multimodalitytherapyforchronicpainsyndromeincriticallowerextremityischemia AT ayunovikov multimodalitytherapyforchronicpainsyndromeincriticallowerextremityischemia AT lvsorokina multimodalitytherapyforchronicpainsyndromeincriticallowerextremityischemia AT avneupokoeva multimodalitytherapyforchronicpainsyndromeincriticallowerextremityischemia |
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1721259956945027072 |