Systemic Inflammation Impairs Mood Function by Disrupting the Resting-State Functional Network in a Rat Animal Model Induced by Lipopolysaccharide Challenge
Background. Systemic inflammation impairs cognitive performance, yet the brain networks mediating this process remain to be elucidated. The purpose of the current study was to use resting-state functional magnetic resonance imaging (fMRI) to explore changes in the functional connectivity in a lipopo...
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2019/6212934 |
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doaj-c97912e6a8a14032a5a8adf72c616d2f2020-11-25T01:35:52ZengHindawi LimitedMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/62129346212934Systemic Inflammation Impairs Mood Function by Disrupting the Resting-State Functional Network in a Rat Animal Model Induced by Lipopolysaccharide ChallengeXia Zhu0Mu-Huo Ji1Shu-Ming Li2Bin Li3Li Mei4Jian-Jun Yang5Department of Anesthesiology, Jinling Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Anesthesiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu, ChinaDepartment of Anesthesiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu, ChinaDepartment of Anesthesiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu, ChinaDepartment of Anesthesiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaDepartment of Anesthesiology, Jinling Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, ChinaBackground. Systemic inflammation impairs cognitive performance, yet the brain networks mediating this process remain to be elucidated. The purpose of the current study was to use resting-state functional magnetic resonance imaging (fMRI) to explore changes in the functional connectivity in a lipopolysaccharide- (LPS-) induced systemic inflammation animal model. Materials and Methods. We used the regional homogeneity (ReHo) method to examine abnormal brain regions between the control and LPS groups and then considered them as seeds of functional connectivity analysis. Results. Compared with the control group, our study showed that (1) LPS impaired mood function, as reflected by a depression-like behavior in the forced swim test; (2) LPS induced significantly increased ReHo values in the anterior cingulate cortex (ACC) and caudate putamen (CPu); (3) the ACC seed showed increased functional connectivity with the retrosplenial cortex, superior colliculus, and inferior colliculus; and (4) the right CPu seed showed increased functional connectivity with the left CPu. Linear regression analysis showed a LPS-induced depression-like behavior which was associated with increased ReHo values in the ACC and right CPu. Moreover, the LPS-induced depression-like behavior was related to increased functional connectivity between the right CPu and left CPu. Conclusion. This is the first study to show that systemic inflammation impairs mood function that is associated with an altered resting-state functional network based on ReHo analysis, providing evidence of the abnormal regional brain spontaneous activity which might be involved in inflammation-related neurobehavioral abnormalities.http://dx.doi.org/10.1155/2019/6212934 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xia Zhu Mu-Huo Ji Shu-Ming Li Bin Li Li Mei Jian-Jun Yang |
spellingShingle |
Xia Zhu Mu-Huo Ji Shu-Ming Li Bin Li Li Mei Jian-Jun Yang Systemic Inflammation Impairs Mood Function by Disrupting the Resting-State Functional Network in a Rat Animal Model Induced by Lipopolysaccharide Challenge Mediators of Inflammation |
author_facet |
Xia Zhu Mu-Huo Ji Shu-Ming Li Bin Li Li Mei Jian-Jun Yang |
author_sort |
Xia Zhu |
title |
Systemic Inflammation Impairs Mood Function by Disrupting the Resting-State Functional Network in a Rat Animal Model Induced by Lipopolysaccharide Challenge |
title_short |
Systemic Inflammation Impairs Mood Function by Disrupting the Resting-State Functional Network in a Rat Animal Model Induced by Lipopolysaccharide Challenge |
title_full |
Systemic Inflammation Impairs Mood Function by Disrupting the Resting-State Functional Network in a Rat Animal Model Induced by Lipopolysaccharide Challenge |
title_fullStr |
Systemic Inflammation Impairs Mood Function by Disrupting the Resting-State Functional Network in a Rat Animal Model Induced by Lipopolysaccharide Challenge |
title_full_unstemmed |
Systemic Inflammation Impairs Mood Function by Disrupting the Resting-State Functional Network in a Rat Animal Model Induced by Lipopolysaccharide Challenge |
title_sort |
systemic inflammation impairs mood function by disrupting the resting-state functional network in a rat animal model induced by lipopolysaccharide challenge |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2019-01-01 |
description |
Background. Systemic inflammation impairs cognitive performance, yet the brain networks mediating this process remain to be elucidated. The purpose of the current study was to use resting-state functional magnetic resonance imaging (fMRI) to explore changes in the functional connectivity in a lipopolysaccharide- (LPS-) induced systemic inflammation animal model. Materials and Methods. We used the regional homogeneity (ReHo) method to examine abnormal brain regions between the control and LPS groups and then considered them as seeds of functional connectivity analysis. Results. Compared with the control group, our study showed that (1) LPS impaired mood function, as reflected by a depression-like behavior in the forced swim test; (2) LPS induced significantly increased ReHo values in the anterior cingulate cortex (ACC) and caudate putamen (CPu); (3) the ACC seed showed increased functional connectivity with the retrosplenial cortex, superior colliculus, and inferior colliculus; and (4) the right CPu seed showed increased functional connectivity with the left CPu. Linear regression analysis showed a LPS-induced depression-like behavior which was associated with increased ReHo values in the ACC and right CPu. Moreover, the LPS-induced depression-like behavior was related to increased functional connectivity between the right CPu and left CPu. Conclusion. This is the first study to show that systemic inflammation impairs mood function that is associated with an altered resting-state functional network based on ReHo analysis, providing evidence of the abnormal regional brain spontaneous activity which might be involved in inflammation-related neurobehavioral abnormalities. |
url |
http://dx.doi.org/10.1155/2019/6212934 |
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