Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function
Zinc (Zn) deficiency is a prevalent micronutrient insufficiency. Although the gut is a vital organ for Zn utilization, and Zn deficiency is associated with impaired intestinal permeability and a global decrease in gastrointestinal health, alterations in the gut microbial ecology of the host under co...
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doaj-c97e96d658894ea5b67bf97eecf4e3222020-11-24T23:55:28ZengMDPI AGNutrients2072-66432015-11-017129768978410.3390/nu7125497nu7125497Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and FunctionSpenser Reed0Hadar Neuman1Sharon Moscovich2Raymond P. Glahn3Omry Koren4Elad Tako5USDA-ARS Robert Holley Center for Agriculture and Health, Ithaca, NY 14853, USAFaculty of Medicine, Bar-Ilan University, 8 Henrietta Szold St, Safed 1311502, IsraelFaculty of Medicine, Bar-Ilan University, 8 Henrietta Szold St, Safed 1311502, IsraelUSDA-ARS Robert Holley Center for Agriculture and Health, Ithaca, NY 14853, USAFaculty of Medicine, Bar-Ilan University, 8 Henrietta Szold St, Safed 1311502, IsraelUSDA-ARS Robert Holley Center for Agriculture and Health, Ithaca, NY 14853, USAZinc (Zn) deficiency is a prevalent micronutrient insufficiency. Although the gut is a vital organ for Zn utilization, and Zn deficiency is associated with impaired intestinal permeability and a global decrease in gastrointestinal health, alterations in the gut microbial ecology of the host under conditions of Zn deficiency have yet to be studied. Using the broiler chicken (Gallus gallus) model, the aim of this study was to characterize distinct cecal microbiota shifts induced by chronic dietary Zn depletion. We demonstrate that Zn deficiency induces significant taxonomic alterations and decreases overall species richness and diversity, establishing a microbial profile resembling that of various other pathological states. Through metagenomic analysis, we show that predicted Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways responsible for macro- and micronutrient uptake are significantly depleted under Zn deficiency; along with concomitant decreases in beneficial short chain fatty acids, such depletions may further preclude optimal host Zn availability. We also identify several candidate microbes that may play a significant role in modulating the bioavailability and utilization of dietary Zn during prolonged deficiency. Our results are the first to characterize a unique and dysbiotic cecal microbiota during Zn deficiency, and provide evidence for such microbial perturbations as potential effectors of the Zn deficient phenotype.http://www.mdpi.com/2072-6643/7/12/5497zinc deficiencymicrobiotadysbiosiscecal microbiomezinc biomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Spenser Reed Hadar Neuman Sharon Moscovich Raymond P. Glahn Omry Koren Elad Tako |
spellingShingle |
Spenser Reed Hadar Neuman Sharon Moscovich Raymond P. Glahn Omry Koren Elad Tako Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function Nutrients zinc deficiency microbiota dysbiosis cecal microbiome zinc biomarker |
author_facet |
Spenser Reed Hadar Neuman Sharon Moscovich Raymond P. Glahn Omry Koren Elad Tako |
author_sort |
Spenser Reed |
title |
Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function |
title_short |
Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function |
title_full |
Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function |
title_fullStr |
Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function |
title_full_unstemmed |
Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function |
title_sort |
chronic zinc deficiency alters chick gut microbiota composition and function |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2015-11-01 |
description |
Zinc (Zn) deficiency is a prevalent micronutrient insufficiency. Although the gut is a vital organ for Zn utilization, and Zn deficiency is associated with impaired intestinal permeability and a global decrease in gastrointestinal health, alterations in the gut microbial ecology of the host under conditions of Zn deficiency have yet to be studied. Using the broiler chicken (Gallus gallus) model, the aim of this study was to characterize distinct cecal microbiota shifts induced by chronic dietary Zn depletion. We demonstrate that Zn deficiency induces significant taxonomic alterations and decreases overall species richness and diversity, establishing a microbial profile resembling that of various other pathological states. Through metagenomic analysis, we show that predicted Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways responsible for macro- and micronutrient uptake are significantly depleted under Zn deficiency; along with concomitant decreases in beneficial short chain fatty acids, such depletions may further preclude optimal host Zn availability. We also identify several candidate microbes that may play a significant role in modulating the bioavailability and utilization of dietary Zn during prolonged deficiency. Our results are the first to characterize a unique and dysbiotic cecal microbiota during Zn deficiency, and provide evidence for such microbial perturbations as potential effectors of the Zn deficient phenotype. |
topic |
zinc deficiency microbiota dysbiosis cecal microbiome zinc biomarker |
url |
http://www.mdpi.com/2072-6643/7/12/5497 |
work_keys_str_mv |
AT spenserreed chroniczincdeficiencyalterschickgutmicrobiotacompositionandfunction AT hadarneuman chroniczincdeficiencyalterschickgutmicrobiotacompositionandfunction AT sharonmoscovich chroniczincdeficiencyalterschickgutmicrobiotacompositionandfunction AT raymondpglahn chroniczincdeficiencyalterschickgutmicrobiotacompositionandfunction AT omrykoren chroniczincdeficiencyalterschickgutmicrobiotacompositionandfunction AT eladtako chroniczincdeficiencyalterschickgutmicrobiotacompositionandfunction |
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