Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event

Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event

The standard model of multiple myeloma (MM) oncogenesis is based on the genetic instability of MM cells and presents its evolution as the emergence of clones with more and more aggressive genotypes, giving them surviving and proliferating advantage. The micro-environment has a passive role. In contr...

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Bibliographic Details
Main Authors: Jean-Pascal Capp, Régis Bataille
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Oncology
Subjects:
multiple myeloma
MGUS
oncogenesis
plasma cells
endosteal niche
bone lesion
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00355/full

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