Induction of immunosuppressive functions and NF-κB by FLIP in monocytes
Signaling and transcriptional regulation of MDSC activity remains largely undefined. Here the authors show that monocytic MDSC immunosuppression is triggered by c-FLIP and requires NFκB, implicate this axis in cancer prognosis and response to therapy, and employ ectopic FLIP to treat immunopathology...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07654-4 |
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doaj-c988a8bcde8c4a15aa07366b491c041d2021-05-11T10:25:14ZengNature Publishing GroupNature Communications2041-17232018-12-019111310.1038/s41467-018-07654-4Induction of immunosuppressive functions and NF-κB by FLIP in monocytesAlessandra Fiore0Stefano Ugel1Francesco De Sanctis2Sara Sandri3Giulio Fracasso4Rosalinda Trovato5Silvia Sartoris6Samantha Solito7Susanna Mandruzzato8Fulvia Vascotto9Keli L. Hippen10Giada Mondanelli11Ursula Grohmann12Geny Piro13Carmine Carbone14Davide Melisi15Rita T. Lawlor16Aldo Scarpa17Alessia Lamolinara18Manuela Iezzi19Matteo Fassan20Silvio Bicciato21Bruce R. Blazar22Ugur Sahin23Peter J. Murray24Vincenzo Bronte25Department of Medicine, Section of Immunology, University of VeronaDepartment of Medicine, Section of Immunology, University of VeronaDepartment of Medicine, Section of Immunology, University of VeronaDepartment of Medicine, Section of Immunology, University of VeronaDepartment of Medicine, Section of Immunology, University of VeronaDepartment of Medicine, Section of Immunology, University of VeronaDepartment of Medicine, Section of Immunology, University of VeronaDepartment of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of PadovaDepartment of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of PadovaTRON-Translational Oncology, University Medical Center of Johannes Gutenberg UniversityDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of MinnesotaDepartment of Experimental Medicine, University of PerugiaDepartment of Experimental Medicine, University of PerugiaDepartment of Medicine, Digestive Molecular Clinical Oncology Research Unit, University of VeronaDepartment of Medicine, Digestive Molecular Clinical Oncology Research Unit, University of VeronaDepartment of Medicine, Digestive Molecular Clinical Oncology Research Unit, University of VeronaARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of VeronaARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of VeronaDepartment of Medicine and Aging Science, Center of Excellence on Aging and Translational Medicine (CeSi-Met), University G. D’Annunzio of Chieti-PescaraDepartment of Medicine and Aging Science, Center of Excellence on Aging and Translational Medicine (CeSi-Met), University G. D’Annunzio of Chieti-PescaraDepartment of Medicine-DIMED, University of PadovaDepartment of Life Sciences, Center for Genome Research, University of Modena and Reggio EmiliaDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of MinnesotaTRON-Translational Oncology, University Medical Center of Johannes Gutenberg UniversityMax Planck Institute of BiochemistryDepartment of Medicine, Section of Immunology, University of VeronaSignaling and transcriptional regulation of MDSC activity remains largely undefined. Here the authors show that monocytic MDSC immunosuppression is triggered by c-FLIP and requires NFκB, implicate this axis in cancer prognosis and response to therapy, and employ ectopic FLIP to treat immunopathology.https://doi.org/10.1038/s41467-018-07654-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Alessandra Fiore Stefano Ugel Francesco De Sanctis Sara Sandri Giulio Fracasso Rosalinda Trovato Silvia Sartoris Samantha Solito Susanna Mandruzzato Fulvia Vascotto Keli L. Hippen Giada Mondanelli Ursula Grohmann Geny Piro Carmine Carbone Davide Melisi Rita T. Lawlor Aldo Scarpa Alessia Lamolinara Manuela Iezzi Matteo Fassan Silvio Bicciato Bruce R. Blazar Ugur Sahin Peter J. Murray Vincenzo Bronte |
| spellingShingle |
Alessandra Fiore Stefano Ugel Francesco De Sanctis Sara Sandri Giulio Fracasso Rosalinda Trovato Silvia Sartoris Samantha Solito Susanna Mandruzzato Fulvia Vascotto Keli L. Hippen Giada Mondanelli Ursula Grohmann Geny Piro Carmine Carbone Davide Melisi Rita T. Lawlor Aldo Scarpa Alessia Lamolinara Manuela Iezzi Matteo Fassan Silvio Bicciato Bruce R. Blazar Ugur Sahin Peter J. Murray Vincenzo Bronte Induction of immunosuppressive functions and NF-κB by FLIP in monocytes Nature Communications |
| author_facet |
Alessandra Fiore Stefano Ugel Francesco De Sanctis Sara Sandri Giulio Fracasso Rosalinda Trovato Silvia Sartoris Samantha Solito Susanna Mandruzzato Fulvia Vascotto Keli L. Hippen Giada Mondanelli Ursula Grohmann Geny Piro Carmine Carbone Davide Melisi Rita T. Lawlor Aldo Scarpa Alessia Lamolinara Manuela Iezzi Matteo Fassan Silvio Bicciato Bruce R. Blazar Ugur Sahin Peter J. Murray Vincenzo Bronte |
| author_sort |
Alessandra Fiore |
| title |
Induction of immunosuppressive functions and NF-κB by FLIP in monocytes |
| title_short |
Induction of immunosuppressive functions and NF-κB by FLIP in monocytes |
| title_full |
Induction of immunosuppressive functions and NF-κB by FLIP in monocytes |
| title_fullStr |
Induction of immunosuppressive functions and NF-κB by FLIP in monocytes |
| title_full_unstemmed |
Induction of immunosuppressive functions and NF-κB by FLIP in monocytes |
| title_sort |
induction of immunosuppressive functions and nf-κb by flip in monocytes |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-12-01 |
| description |
Signaling and transcriptional regulation of MDSC activity remains largely undefined. Here the authors show that monocytic MDSC immunosuppression is triggered by c-FLIP and requires NFκB, implicate this axis in cancer prognosis and response to therapy, and employ ectopic FLIP to treat immunopathology. |
| url |
https://doi.org/10.1038/s41467-018-07654-4 |
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