Induction of immunosuppressive functions and NF-κB by FLIP in monocytes
Signaling and transcriptional regulation of MDSC activity remains largely undefined. Here the authors show that monocytic MDSC immunosuppression is triggered by c-FLIP and requires NFκB, implicate this axis in cancer prognosis and response to therapy, and employ ectopic FLIP to treat immunopathology...
Main Authors: | Alessandra Fiore, Stefano Ugel, Francesco De Sanctis, Sara Sandri, Giulio Fracasso, Rosalinda Trovato, Silvia Sartoris, Samantha Solito, Susanna Mandruzzato, Fulvia Vascotto, Keli L. Hippen, Giada Mondanelli, Ursula Grohmann, Geny Piro, Carmine Carbone, Davide Melisi, Rita T. Lawlor, Aldo Scarpa, Alessia Lamolinara, Manuela Iezzi, Matteo Fassan, Silvio Bicciato, Bruce R. Blazar, Ugur Sahin, Peter J. Murray, Vincenzo Bronte |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-12-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-07654-4 |
Similar Items
-
The Endless Saga of Monocyte Diversity
by: Stefania Canè, et al.
Published: (2019-08-01) -
Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3
by: Rosalinda Trovato, et al.
Published: (2019-09-01) -
The Engagement Between MDSCs and Metastases: Partners in Crime
by: Rosalinda Trovato, et al.
Published: (2020-02-01) -
Gene expression profiling of human fibrocytic myeloid-derived suppressor cells (f-MDSCs)
by: Emilia Maria Cristina Mazza, et al.
Published: (2014-12-01) -
The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment
by: Francesco eDe Sanctis, et al.
Published: (2014-02-01)