Intrinsic limits to gene regulation by global crosstalk
Limited specificity of transcription factor-DNA interactions leads to crosstalk in gene regulation. Here the authors consider global crosstalk in regulatory networks of growing size and complexity, and show that it imposes constraints on gene regulation and on the evolution of regulatory networks.
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms12307 |
id |
doaj-c992d8eba18c4f6c9db2333ee90aa8f3 |
---|---|
record_format |
Article |
spelling |
doaj-c992d8eba18c4f6c9db2333ee90aa8f32021-05-11T11:18:57ZengNature Publishing GroupNature Communications2041-17232016-08-017111210.1038/ncomms12307Intrinsic limits to gene regulation by global crosstalkTamar Friedlander0Roshan Prizak1Călin C. Guet2Nicholas H. Barton3Gašper Tkačik4Institute of Science and Technology AustriaInstitute of Science and Technology AustriaInstitute of Science and Technology AustriaInstitute of Science and Technology AustriaInstitute of Science and Technology AustriaLimited specificity of transcription factor-DNA interactions leads to crosstalk in gene regulation. Here the authors consider global crosstalk in regulatory networks of growing size and complexity, and show that it imposes constraints on gene regulation and on the evolution of regulatory networks.https://doi.org/10.1038/ncomms12307 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tamar Friedlander Roshan Prizak Călin C. Guet Nicholas H. Barton Gašper Tkačik |
spellingShingle |
Tamar Friedlander Roshan Prizak Călin C. Guet Nicholas H. Barton Gašper Tkačik Intrinsic limits to gene regulation by global crosstalk Nature Communications |
author_facet |
Tamar Friedlander Roshan Prizak Călin C. Guet Nicholas H. Barton Gašper Tkačik |
author_sort |
Tamar Friedlander |
title |
Intrinsic limits to gene regulation by global crosstalk |
title_short |
Intrinsic limits to gene regulation by global crosstalk |
title_full |
Intrinsic limits to gene regulation by global crosstalk |
title_fullStr |
Intrinsic limits to gene regulation by global crosstalk |
title_full_unstemmed |
Intrinsic limits to gene regulation by global crosstalk |
title_sort |
intrinsic limits to gene regulation by global crosstalk |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2016-08-01 |
description |
Limited specificity of transcription factor-DNA interactions leads to crosstalk in gene regulation. Here the authors consider global crosstalk in regulatory networks of growing size and complexity, and show that it imposes constraints on gene regulation and on the evolution of regulatory networks. |
url |
https://doi.org/10.1038/ncomms12307 |
work_keys_str_mv |
AT tamarfriedlander intrinsiclimitstogeneregulationbyglobalcrosstalk AT roshanprizak intrinsiclimitstogeneregulationbyglobalcrosstalk AT calincguet intrinsiclimitstogeneregulationbyglobalcrosstalk AT nicholashbarton intrinsiclimitstogeneregulationbyglobalcrosstalk AT gaspertkacik intrinsiclimitstogeneregulationbyglobalcrosstalk |
_version_ |
1721446792846901248 |