Intrinsic limits to gene regulation by global crosstalk

Limited specificity of transcription factor-DNA interactions leads to crosstalk in gene regulation. Here the authors consider global crosstalk in regulatory networks of growing size and complexity, and show that it imposes constraints on gene regulation and on the evolution of regulatory networks.

Bibliographic Details
Main Authors:	Tamar Friedlander, Roshan Prizak, Călin C. Guet, Nicholas H. Barton, Gašper Tkačik
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12307

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spelling	doaj-c992d8eba18c4f6c9db2333ee90aa8f32021-05-11T11:18:57ZengNature Publishing GroupNature Communications2041-17232016-08-017111210.1038/ncomms12307Intrinsic limits to gene regulation by global crosstalkTamar Friedlander0Roshan Prizak1Călin C. Guet2Nicholas H. Barton3Gašper Tkačik4Institute of Science and Technology AustriaInstitute of Science and Technology AustriaInstitute of Science and Technology AustriaInstitute of Science and Technology AustriaInstitute of Science and Technology AustriaLimited specificity of transcription factor-DNA interactions leads to crosstalk in gene regulation. Here the authors consider global crosstalk in regulatory networks of growing size and complexity, and show that it imposes constraints on gene regulation and on the evolution of regulatory networks.https://doi.org/10.1038/ncomms12307
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tamar Friedlander Roshan Prizak Călin C. Guet Nicholas H. Barton Gašper Tkačik
spellingShingle	Tamar Friedlander Roshan Prizak Călin C. Guet Nicholas H. Barton Gašper Tkačik Intrinsic limits to gene regulation by global crosstalk Nature Communications
author_facet	Tamar Friedlander Roshan Prizak Călin C. Guet Nicholas H. Barton Gašper Tkačik
author_sort	Tamar Friedlander
title	Intrinsic limits to gene regulation by global crosstalk
title_short	Intrinsic limits to gene regulation by global crosstalk
title_full	Intrinsic limits to gene regulation by global crosstalk
title_fullStr	Intrinsic limits to gene regulation by global crosstalk
title_full_unstemmed	Intrinsic limits to gene regulation by global crosstalk
title_sort	intrinsic limits to gene regulation by global crosstalk
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-08-01
description	Limited specificity of transcription factor-DNA interactions leads to crosstalk in gene regulation. Here the authors consider global crosstalk in regulatory networks of growing size and complexity, and show that it imposes constraints on gene regulation and on the evolution of regulatory networks.
url	https://doi.org/10.1038/ncomms12307
work_keys_str_mv	AT tamarfriedlander intrinsiclimitstogeneregulationbyglobalcrosstalk AT roshanprizak intrinsiclimitstogeneregulationbyglobalcrosstalk AT calincguet intrinsiclimitstogeneregulationbyglobalcrosstalk AT nicholashbarton intrinsiclimitstogeneregulationbyglobalcrosstalk AT gaspertkacik intrinsiclimitstogeneregulationbyglobalcrosstalk
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Intrinsic limits to gene regulation by global crosstalk

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