Association of Metabolic Syndrome with the Adiponectin to Homeostasis Model Assessment of Insulin Resistance Ratio

• Main Authors: Yu-Song Ding, Shu-Xia Guo, Ru-Lin Ma, Shu-Gang Li, Heng Guo, Jing-Yu Zhang, Mei Zhang, Jia-Ming Liu, Jia He, Yi-zhong Yan, Wen-Jie Zhang, Lie-Gang Liu
• Format: Article
• Language: English
• Published: Hindawi Limited 2015-01-01
• Series: Mediators of Inflammation
• Online Access: http://dx.doi.org/10.1155/2015/607364

This study aimed at determining whether the adiponectin to HOMA-IR (A/H) ratio is associated with MetS and MetS components and comparing the diagnostic efficacy of adiponectin, HOMA-IR, and the A/H ratio in healthy, middle-aged participants. MetS was assessed in 1628 Kazakh participants (men, 768; women, 860). The associations between adiponectin, HOMA-IR, and the A/H ratio with the components of MetS and MetS were examined using logistic regression analysis and receiver operating characteristic (ROC) curves. Our results show that A/H ratio may be a better diagnostic marker for MetS than either HOMA-IR or adiponectin alone, and it may serve as an important biomarker to determine an increased risk for MetS in healthy middle-aged population.