PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
Antibody mediated immune responses to Streptococcus pneumoniae are crucial for the immune response to infection. Here the authors show hyper-activation of PI3Kδ promotes development of a subset of B cells that exacerbate infection in an antibody-independent manner and can be reversed by therapeutic...
Main Authors: | Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, Rafeah Alam, Valentina Carbonaro, Jonathan Clark, Srividya Sriskantharajah, Glyn Bradley, Alex G. Richter, Edward Banham-Hall, Menna R. Clatworthy, Sergey Nejentsev, J. Nicole Hamblin, Edith M. Hessel, Alison M. Condliffe, Klaus Okkenhaug |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-05674-8 |
Similar Items
-
The role of IKK-induced NF-κB1 p105 proteolysis in T lymphocytes
by: Sriskantharajah, Srividya
Published: (2008) -
δ-Primary Hyperideals on Commutative Hyperrings
by: Elif Ozel Ay, et al.
Published: (2017-01-01) -
Corrigendum to “δ-Primary Hyperideals on Commutative Hyperrings”
by: Elif Özel Ay
Published: (2018-01-01) -
IgG and Fcγ Receptors in Intestinal Immunity and Inflammation
by: Tomas Castro-Dopico, et al.
Published: (2019-04-01) -
Fusobacterium nucleatum Causes Microbial Dysbiosis and Exacerbates Visceral Hypersensitivity in a Colonization-Independent Manner
by: Xiang Gu, et al.
Published: (2020-06-01)