Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study

Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study

Protein kinases are a large class of enzymes with numerous biological roles and many have been implicated in a vast array of diseases, including cancer and the novel coronavirus infection COVID-19. Thus, the development of chemical probes to selectively target each kinase is of great interest. Inhib...

Full description

Bibliographic Details
Main Authors: Eleanor L. Atkinson, Jessica Iegre, Paul D. Brear, Elizabeth A. Zhabina, Marko Hyvönen, David R. Spring
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
kinase
CK2
inhibitor
cancer
molecular probe
ATP-site
Online Access:https://www.mdpi.com/1420-3049/26/7/1977

Similar Items

Similar Items