An Overview of the Relevance of IgG4 Antibodies in Allergic Disease with a Focus on Food Allergens

An Overview of the Relevance of IgG4 Antibodies in Allergic Disease with a Focus on Food Allergens

Antibodies of the IgG4 isotype are strongly associated with allergic disease but have several properties such as not precipitating with allergens, not activating complement and poor binding to Fcγ receptors that argue against a pro-inflammatory role. In keeping with that, IgG4 antibodies are a strik...

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Bibliographic Details
Main Authors: Thomas A. E. Platts-Mills, Behnam Keshavarz, Jeffrey M. Wilson, Rung-chi Li, Peter W. Heymann, Diane R. Gold, Emily C. McGowan, Elizabeth A. Erwin
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Children
Subjects:
food allergy
IgG4 antibody
Fab-arm exchange
eosinophilic esophagitis
milk
wheat
Online Access:https://www.mdpi.com/2227-9067/8/5/418

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