c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes
Beyond its well-admitted role in development and organogenesis, it is now clear that the transcription factor c-Maf has owned its place in the realm of immune-related transcription factors. Formerly introduced solely as a Th2 transcription factor, the role attributed to c-Maf has gradually broadened...
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doaj-c9bf6488e64c4892b12a1b7b6e365c962020-11-25T01:06:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-02-011110.3389/fimmu.2020.00206520749c-MAF, a Swiss Army Knife for Tolerance in LymphocytesClaire Imbratta0Hind Hussein1Fabienne Andris2Grégory Verdeil3Department of Oncology, University of Lausanne, Lausanne, SwitzerlandLaboratoire d'Immunobiologie, Université Libre de Bruxelles, Brussels, BelgiumLaboratoire d'Immunobiologie, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Oncology, University of Lausanne, Lausanne, SwitzerlandBeyond its well-admitted role in development and organogenesis, it is now clear that the transcription factor c-Maf has owned its place in the realm of immune-related transcription factors. Formerly introduced solely as a Th2 transcription factor, the role attributed to c-Maf has gradually broadened over the years and has extended to most, if not all, known immune cell types. The influence of c-Maf is particularly prominent among T cell subsets, where c-Maf regulates the differentiation as well as the function of multiple subsets of CD4 and CD8 T cells, lending it a crucial position in adaptive immunity and anti-tumoral responsiveness. Recent research has also revealed the role of c-Maf in controlling Th17 responses in the intestine, positioning it as an essential factor in intestinal homeostasis. This review aims to present and discuss the recent advances highlighting the particular role played by c-Maf in T lymphocyte differentiation, function, and homeostasis.https://www.frontiersin.org/article/10.3389/fimmu.2020.00206/fullT cellstolerancec-Mafinterleukin-10gut |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claire Imbratta Hind Hussein Fabienne Andris Grégory Verdeil |
spellingShingle |
Claire Imbratta Hind Hussein Fabienne Andris Grégory Verdeil c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes Frontiers in Immunology T cells tolerance c-Maf interleukin-10 gut |
author_facet |
Claire Imbratta Hind Hussein Fabienne Andris Grégory Verdeil |
author_sort |
Claire Imbratta |
title |
c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes |
title_short |
c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes |
title_full |
c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes |
title_fullStr |
c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes |
title_full_unstemmed |
c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes |
title_sort |
c-maf, a swiss army knife for tolerance in lymphocytes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-02-01 |
description |
Beyond its well-admitted role in development and organogenesis, it is now clear that the transcription factor c-Maf has owned its place in the realm of immune-related transcription factors. Formerly introduced solely as a Th2 transcription factor, the role attributed to c-Maf has gradually broadened over the years and has extended to most, if not all, known immune cell types. The influence of c-Maf is particularly prominent among T cell subsets, where c-Maf regulates the differentiation as well as the function of multiple subsets of CD4 and CD8 T cells, lending it a crucial position in adaptive immunity and anti-tumoral responsiveness. Recent research has also revealed the role of c-Maf in controlling Th17 responses in the intestine, positioning it as an essential factor in intestinal homeostasis. This review aims to present and discuss the recent advances highlighting the particular role played by c-Maf in T lymphocyte differentiation, function, and homeostasis. |
topic |
T cells tolerance c-Maf interleukin-10 gut |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.00206/full |
work_keys_str_mv |
AT claireimbratta cmafaswissarmyknifefortoleranceinlymphocytes AT hindhussein cmafaswissarmyknifefortoleranceinlymphocytes AT fabienneandris cmafaswissarmyknifefortoleranceinlymphocytes AT gregoryverdeil cmafaswissarmyknifefortoleranceinlymphocytes |
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