Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: results from two longitudinal studies
Abstract Background Anxiety disorders in adolescence have been associated with several psychiatric outcomes. We sought to describe the prospective relationship between various levels of adolescent anxiety and psychiatric diagnoses (anxiety-, bipolar/psychotic-, depressive-, and alcohol and drug misu...
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doaj-c9e308cde7474f19b7b59b7f1c0aee222020-11-25T04:10:01ZengBMCBMC Psychiatry1471-244X2019-11-0119111110.1186/s12888-019-2349-3Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: results from two longitudinal studiesSabrina Doering0Paul Lichtenstein1Christopher Gillberg2NTRChristel M. Middeldorp3Meike Bartels4Ralf Kuja-Halkola5Sebastian Lundström6Centre for Ethics, Law and Mental Health, University of GothenburgDepartment of Medical Epidemiology and Biostatics, Karolinska InstitutetGillberg Neuropsychiatry Centre, University of GothenburgDepartment of Biological Psychology, Vrije Universiteit AmsterdamDepartment of Biological Psychology, Vrije Universiteit AmsterdamDepartment of Medical Epidemiology and Biostatics, Karolinska InstitutetCentre for Ethics, Law and Mental Health, University of GothenburgAbstract Background Anxiety disorders in adolescence have been associated with several psychiatric outcomes. We sought to describe the prospective relationship between various levels of adolescent anxiety and psychiatric diagnoses (anxiety-, bipolar/psychotic-, depressive-, and alcohol and drug misuse disorders) and suicidal ideation in early adulthood while adjusting for childhood attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and developmental coordination disorder (DCD). Furthermore, we aimed to estimate the proportion attributable to the various anxiety levels for the outcomes. Methods We used a nation-wide population-based Swedish twin study comprising 14,106 fifteen-year-old twins born in Sweden between 1994 and 2002 and a replication sample consisting of 9211 Dutch twins, born between 1985 and 1999. Adolescent anxiety was measured with parental and self-report. Psychiatric diagnoses and suicidal ideation were retrieved from the Swedish National Patient Register and via self-report. Results Adolescent anxiety, of various levels, predicted, in the Swedish National Patient Register, anxiety disorders: hazard ratio (HR) = 4.92 (CI 3.33–7.28); depressive disorders: HR = 4.79 (3.23–7.08), and any psychiatric outcome: HR = 3.40 (2.58–4.48), when adjusting for ADHD, ASD, and DCD. The results were replicated in the Dutch data. The proportion of psychiatric outcome attributable to adolescent anxiety over time (age 15–21) was 29% for any psychiatric outcome, 43–40% for anxiety disorders, and 39–38% for depressive disorders. Conclusion Anxiety in adolescence constitutes an important risk factor in the development of psychiatric outcomes, revealing unique predictions for the different levels of anxiety, and beyond the risk conferred by childhood ADHD, ASD, and DCD. Developmental trajectories leading into psychiatric outcomes should further empirically investigated.http://link.springer.com/article/10.1186/s12888-019-2349-3AdolescenceYoung adulthoodNeurodevelopmental disordersAnxiety disordersDepressive disordersSuicidal ideation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sabrina Doering Paul Lichtenstein Christopher Gillberg NTR Christel M. Middeldorp Meike Bartels Ralf Kuja-Halkola Sebastian Lundström |
spellingShingle |
Sabrina Doering Paul Lichtenstein Christopher Gillberg NTR Christel M. Middeldorp Meike Bartels Ralf Kuja-Halkola Sebastian Lundström Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: results from two longitudinal studies BMC Psychiatry Adolescence Young adulthood Neurodevelopmental disorders Anxiety disorders Depressive disorders Suicidal ideation |
author_facet |
Sabrina Doering Paul Lichtenstein Christopher Gillberg NTR Christel M. Middeldorp Meike Bartels Ralf Kuja-Halkola Sebastian Lundström |
author_sort |
Sabrina Doering |
title |
Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: results from two longitudinal studies |
title_short |
Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: results from two longitudinal studies |
title_full |
Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: results from two longitudinal studies |
title_fullStr |
Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: results from two longitudinal studies |
title_full_unstemmed |
Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: results from two longitudinal studies |
title_sort |
anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: results from two longitudinal studies |
publisher |
BMC |
series |
BMC Psychiatry |
issn |
1471-244X |
publishDate |
2019-11-01 |
description |
Abstract Background Anxiety disorders in adolescence have been associated with several psychiatric outcomes. We sought to describe the prospective relationship between various levels of adolescent anxiety and psychiatric diagnoses (anxiety-, bipolar/psychotic-, depressive-, and alcohol and drug misuse disorders) and suicidal ideation in early adulthood while adjusting for childhood attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and developmental coordination disorder (DCD). Furthermore, we aimed to estimate the proportion attributable to the various anxiety levels for the outcomes. Methods We used a nation-wide population-based Swedish twin study comprising 14,106 fifteen-year-old twins born in Sweden between 1994 and 2002 and a replication sample consisting of 9211 Dutch twins, born between 1985 and 1999. Adolescent anxiety was measured with parental and self-report. Psychiatric diagnoses and suicidal ideation were retrieved from the Swedish National Patient Register and via self-report. Results Adolescent anxiety, of various levels, predicted, in the Swedish National Patient Register, anxiety disorders: hazard ratio (HR) = 4.92 (CI 3.33–7.28); depressive disorders: HR = 4.79 (3.23–7.08), and any psychiatric outcome: HR = 3.40 (2.58–4.48), when adjusting for ADHD, ASD, and DCD. The results were replicated in the Dutch data. The proportion of psychiatric outcome attributable to adolescent anxiety over time (age 15–21) was 29% for any psychiatric outcome, 43–40% for anxiety disorders, and 39–38% for depressive disorders. Conclusion Anxiety in adolescence constitutes an important risk factor in the development of psychiatric outcomes, revealing unique predictions for the different levels of anxiety, and beyond the risk conferred by childhood ADHD, ASD, and DCD. Developmental trajectories leading into psychiatric outcomes should further empirically investigated. |
topic |
Adolescence Young adulthood Neurodevelopmental disorders Anxiety disorders Depressive disorders Suicidal ideation |
url |
http://link.springer.com/article/10.1186/s12888-019-2349-3 |
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