The Progress of Next Generation Sequencing in the Assessment of Myeloid Malignancies
The introduction and advances on next-generation sequencing have led to novel ways to integrate simultaneous assessment of multiple target genes in routine laboratory analysis. Assessment of myeloid neoplasms with targeted next-generation sequencing panels shows evidence to improve diagnosis, assist...
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2019-03-01
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doaj-c9eef730e39b4282b3c6a1d2638d19022020-11-24T21:11:20ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312019-03-01362788710.4274/balkanmedj.galenos.2018.2018.119513049054The Progress of Next Generation Sequencing in the Assessment of Myeloid MalignanciesFulya Öz Puyan0Serhan Alkan1 Department of Pathology, Trakya University School of Medicine, Edirne, Turkey Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, California, USA The introduction and advances on next-generation sequencing have led to novel ways to integrate simultaneous assessment of multiple target genes in routine laboratory analysis. Assessment of myeloid neoplasms with targeted next-generation sequencing panels shows evidence to improve diagnosis, assist therapeutic decisions, provide better information about prognosis, and better detection of minimal residual disease. Herein, we provide information for application and utilization of next-generation sequencing studies with a focus on the most important mutations in acute myeloid leukemia, myelodysplastic syndrome, myeloproliferative neoplasms, and other myelodysplastic/myeloproliferative neoplasms in order to integrate them into the daily clinical practice. http://balkanmedicaljournal.org/archives/archive-detail/article-preview/the-progress-of-next-generation-sequencing-in-the-/25518 Myeloid neoplasianext-generation sequencingsomatic mutation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fulya Öz Puyan Serhan Alkan |
spellingShingle |
Fulya Öz Puyan Serhan Alkan The Progress of Next Generation Sequencing in the Assessment of Myeloid Malignancies Balkan Medical Journal Myeloid neoplasia next-generation sequencing somatic mutation |
author_facet |
Fulya Öz Puyan Serhan Alkan |
author_sort |
Fulya Öz Puyan |
title |
The Progress of Next Generation Sequencing in the Assessment of Myeloid Malignancies |
title_short |
The Progress of Next Generation Sequencing in the Assessment of Myeloid Malignancies |
title_full |
The Progress of Next Generation Sequencing in the Assessment of Myeloid Malignancies |
title_fullStr |
The Progress of Next Generation Sequencing in the Assessment of Myeloid Malignancies |
title_full_unstemmed |
The Progress of Next Generation Sequencing in the Assessment of Myeloid Malignancies |
title_sort |
progress of next generation sequencing in the assessment of myeloid malignancies |
publisher |
Galenos Publishing House |
series |
Balkan Medical Journal |
issn |
2146-3123 2146-3131 |
publishDate |
2019-03-01 |
description |
The introduction and advances on next-generation sequencing have led to novel ways to integrate simultaneous assessment of multiple target genes in routine laboratory analysis. Assessment of myeloid neoplasms with targeted next-generation sequencing panels shows evidence to improve diagnosis, assist therapeutic decisions, provide better information about prognosis, and better detection of minimal residual disease. Herein, we provide information for application and utilization of next-generation sequencing studies with a focus on the most important mutations in acute myeloid leukemia, myelodysplastic syndrome, myeloproliferative neoplasms, and other myelodysplastic/myeloproliferative neoplasms in order to integrate them into the daily clinical practice. |
topic |
Myeloid neoplasia next-generation sequencing somatic mutation |
url |
http://balkanmedicaljournal.org/archives/archive-detail/article-preview/the-progress-of-next-generation-sequencing-in-the-/25518
|
work_keys_str_mv |
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1716753775706767360 |