Naturalistic and Uncontrolled Pilot Study on the Efficacy of Vortioxetine in Binge Eating Disorder With Comorbid Depression
Background: Binge eating disorder (BED) is clinically relevant by virtue of the global impairment, poor quality of life, and increased overall medical morbidity. The high comorbidity with psychiatric disorders, particularly depression, has received attention as a possible mediator of the poor outcom...
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Frontiers Media S.A.
2021-03-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.635502/full |
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English |
format |
Article |
sources |
DOAJ |
author |
Cristina Segura-Garcia Cristina Segura-Garcia Marianna Rania Marianna Rania Elvira Anna Carbone Elvira Anna Carbone Renato de Filippis Renato de Filippis Matteo Aloi Matteo Aloi Mariarita Caroleo Mariarita Caroleo Gloria Grasso Gloria Grasso Giuseppina Calabrò Giuseppina Calabrò Gilda Fazia Gilda Fazia Filippo Antonio Staltari Filippo Antonio Staltari Antonella Falvo Antonella Falvo Valentina Pugliese Valentina Pugliese Raffaele Gaetano Raffaele Gaetano Luca Steardo Luca Steardo Pasquale De Fazio Pasquale De Fazio |
spellingShingle |
Cristina Segura-Garcia Cristina Segura-Garcia Marianna Rania Marianna Rania Elvira Anna Carbone Elvira Anna Carbone Renato de Filippis Renato de Filippis Matteo Aloi Matteo Aloi Mariarita Caroleo Mariarita Caroleo Gloria Grasso Gloria Grasso Giuseppina Calabrò Giuseppina Calabrò Gilda Fazia Gilda Fazia Filippo Antonio Staltari Filippo Antonio Staltari Antonella Falvo Antonella Falvo Valentina Pugliese Valentina Pugliese Raffaele Gaetano Raffaele Gaetano Luca Steardo Luca Steardo Pasquale De Fazio Pasquale De Fazio Naturalistic and Uncontrolled Pilot Study on the Efficacy of Vortioxetine in Binge Eating Disorder With Comorbid Depression Frontiers in Psychiatry vortioxetine Binge Eating Disorder depression neurocognition eating behavior weight |
author_facet |
Cristina Segura-Garcia Cristina Segura-Garcia Marianna Rania Marianna Rania Elvira Anna Carbone Elvira Anna Carbone Renato de Filippis Renato de Filippis Matteo Aloi Matteo Aloi Mariarita Caroleo Mariarita Caroleo Gloria Grasso Gloria Grasso Giuseppina Calabrò Giuseppina Calabrò Gilda Fazia Gilda Fazia Filippo Antonio Staltari Filippo Antonio Staltari Antonella Falvo Antonella Falvo Valentina Pugliese Valentina Pugliese Raffaele Gaetano Raffaele Gaetano Luca Steardo Luca Steardo Pasquale De Fazio Pasquale De Fazio |
author_sort |
Cristina Segura-Garcia |
title |
Naturalistic and Uncontrolled Pilot Study on the Efficacy of Vortioxetine in Binge Eating Disorder With Comorbid Depression |
title_short |
Naturalistic and Uncontrolled Pilot Study on the Efficacy of Vortioxetine in Binge Eating Disorder With Comorbid Depression |
title_full |
Naturalistic and Uncontrolled Pilot Study on the Efficacy of Vortioxetine in Binge Eating Disorder With Comorbid Depression |
title_fullStr |
Naturalistic and Uncontrolled Pilot Study on the Efficacy of Vortioxetine in Binge Eating Disorder With Comorbid Depression |
title_full_unstemmed |
Naturalistic and Uncontrolled Pilot Study on the Efficacy of Vortioxetine in Binge Eating Disorder With Comorbid Depression |
title_sort |
naturalistic and uncontrolled pilot study on the efficacy of vortioxetine in binge eating disorder with comorbid depression |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2021-03-01 |
description |
Background: Binge eating disorder (BED) is clinically relevant by virtue of the global impairment, poor quality of life, and increased overall medical morbidity. The high comorbidity with psychiatric disorders, particularly depression, has received attention as a possible mediator of the poor outcome. Further, BED and depression share cognitive dysfunctions. This naturalistic and uncontrolled pilot study aimed at evaluating the efficacy of vortioxetine (VTX) on depressive symptoms in patients with BED, secondly the efficacy in improving a broad array of executive functions, and third to explore the effect on eating behavior and body weight.Methods: This pilot study involved 30 patients with BED and comorbid MDD, treated with VTX for 24 weeks. Assessments were run at baseline (t0), 4 (t1), 8 (t2), 12 (t3), and 24 (t4) weeks. Changes in depressive symptoms (HDRS and BDI), executive functions, eating behaviors (binge frequency and severity, night eating, food addiction), and body weight were estimated after treatment with VTX through GLM.Results: Significant improvements emerged after treatment with VTX in: depression (HDRS p < 0.001; BDI p = 0.002) regardless the dose of VTX and first diagnosis (BED/MDD), working memory (RAVLT acquisition p = 0.01, delay recall p < 0.001, RCFT percentage of recall p = 0.01, and Attentional Matrices p = 0.05), binge days frequency (p < 0.001), binge eating severity (BES p < 0.001), night eating (p = 0.001), food addiction (YFAS 2.0 p = 0.039), and body weight (p = 0.039). The improvement in depressive symptoms was associated with the concurrent improvement in night eating as assessed by the I-NEQ.Conclusions: VTX can be a valid therapeutic choice for patients with BED with comorbid depression in controlling the depressive symptoms, working memory, and eating behavior. Indeed, by acting on affective symptoms, neurocognitive functioning, and eating behaviors, it confirms the results already obtained with VTX in other disorders, expanding them to BED. |
topic |
vortioxetine Binge Eating Disorder depression neurocognition eating behavior weight |
url |
https://www.frontiersin.org/articles/10.3389/fpsyt.2021.635502/full |
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doaj-c9f80bec953d4201a09cc93fb4ed523d2021-03-17T04:18:29ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-03-011210.3389/fpsyt.2021.635502635502Naturalistic and Uncontrolled Pilot Study on the Efficacy of Vortioxetine in Binge Eating Disorder With Comorbid DepressionCristina Segura-Garcia0Cristina Segura-Garcia1Marianna Rania2Marianna Rania3Elvira Anna Carbone4Elvira Anna Carbone5Renato de Filippis6Renato de Filippis7Matteo Aloi8Matteo Aloi9Mariarita Caroleo10Mariarita Caroleo11Gloria Grasso12Gloria Grasso13Giuseppina Calabrò14Giuseppina Calabrò15Gilda Fazia16Gilda Fazia17Filippo Antonio Staltari18Filippo Antonio Staltari19Antonella Falvo20Antonella Falvo21Valentina Pugliese22Valentina Pugliese23Raffaele Gaetano24Raffaele Gaetano25Luca Steardo26Luca Steardo27Pasquale De Fazio28Pasquale De Fazio29Psychiatric Unit, Department of Medical and Surgical Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyPsychiatric Unit, Department of Medical and Surgical Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyPsychiatric Unit, Department of Medical and Surgical Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyOutpatient Service for Research and Treatment of Eating Disorders, University Hospital Mater Domini, Catanzaro, ItalyPsychiatric Unit, Department of Health Sciences, University “Magna Graecia”, Catanzaro, ItalyBackground: Binge eating disorder (BED) is clinically relevant by virtue of the global impairment, poor quality of life, and increased overall medical morbidity. The high comorbidity with psychiatric disorders, particularly depression, has received attention as a possible mediator of the poor outcome. Further, BED and depression share cognitive dysfunctions. This naturalistic and uncontrolled pilot study aimed at evaluating the efficacy of vortioxetine (VTX) on depressive symptoms in patients with BED, secondly the efficacy in improving a broad array of executive functions, and third to explore the effect on eating behavior and body weight.Methods: This pilot study involved 30 patients with BED and comorbid MDD, treated with VTX for 24 weeks. Assessments were run at baseline (t0), 4 (t1), 8 (t2), 12 (t3), and 24 (t4) weeks. Changes in depressive symptoms (HDRS and BDI), executive functions, eating behaviors (binge frequency and severity, night eating, food addiction), and body weight were estimated after treatment with VTX through GLM.Results: Significant improvements emerged after treatment with VTX in: depression (HDRS p < 0.001; BDI p = 0.002) regardless the dose of VTX and first diagnosis (BED/MDD), working memory (RAVLT acquisition p = 0.01, delay recall p < 0.001, RCFT percentage of recall p = 0.01, and Attentional Matrices p = 0.05), binge days frequency (p < 0.001), binge eating severity (BES p < 0.001), night eating (p = 0.001), food addiction (YFAS 2.0 p = 0.039), and body weight (p = 0.039). The improvement in depressive symptoms was associated with the concurrent improvement in night eating as assessed by the I-NEQ.Conclusions: VTX can be a valid therapeutic choice for patients with BED with comorbid depression in controlling the depressive symptoms, working memory, and eating behavior. Indeed, by acting on affective symptoms, neurocognitive functioning, and eating behaviors, it confirms the results already obtained with VTX in other disorders, expanding them to BED.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.635502/fullvortioxetineBinge Eating Disorderdepressionneurocognitioneating behaviorweight |