High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status

High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status

Summary: Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in severe, treatment-refractory disease. Applying mass cytometry and machine learning to bronchoalveolar lavage (BAL) cells, we find that corticosteroid-resistant asthma patients cluster largely into two...

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Bibliographic Details
Main Authors: Matthew J. Camiolo, Xiaoying Zhou, Timothy B. Oriss, Qi Yan, Michael Gorry, William Horne, John B. Trudeau, Kathryn Scholl, Wei Chen, Jay K. Kolls, Prabir Ray, Florian J. Weisel, Nadine M. Weisel, Nima Aghaeepour, Kari Nadeau, Sally E. Wenzel, Anuradha Ray
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
severe asthma
BAL
immune
multi-omics
CyTOF
RNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002886

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