HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls

The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according t...

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Main Authors:	Fatma Savran Oguz, Lale Ocal, Ali Sarper Diler, Hilmi Ozkul, Faruk Asicioglu, Esen Kasapoglu, Gokay Bozkurt, Meral Konice, Mahmut Carin
Format:	Article
Language:	English
Published:	Hindawi Limited 2004-01-01
Series:	Disease Markers
Online Access:	http://dx.doi.org/10.1155/2004/565270

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spelling	doaj-c9fa801555dd4204bb1e4bee4422abff2020-11-24T22:31:10ZengHindawi LimitedDisease Markers0278-02401875-86302004-01-0120630931210.1155/2004/565270HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy ControlsFatma Savran Oguz0Lale Ocal1Ali Sarper Diler2Hilmi Ozkul3Faruk Asicioglu4Esen Kasapoglu5Gokay Bozkurt6Meral Konice7Mahmut Carin8Istanbul University, Istanbul Medical Faculty, Department of Medical Biology Istanbul, TurkeyIstanbul University, Istanbul Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, TurkeyIstanbul University, Istanbul Medical Faculty, Department of Medical Biology Istanbul, TurkeyIstanbul University, Istanbul Medical Faculty, Department of Medical Biology Istanbul, TurkeyIstanbul University, Istanbul Medical Faculty, Department of Medical Biology Istanbul, TurkeyIstanbul University, Istanbul Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, TurkeyTrakya University Medical Faculty, Department of Medical Biology. Edirne, TurkeyIstanbul University, Istanbul Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, TurkeyIstanbul University, Istanbul Medical Faculty, Department of Medical Biology Istanbul, TurkeyThe frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B∗27 was 2.6% in the Turkish population, and B∗2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B∗2705 among B27-positive patients and controls was significantly different (P = 0.02). Our study supports other reports from different populations which showed that B∗2705 and B∗2702 were more frequent in Caucasian patients with SpA.http://dx.doi.org/10.1155/2004/565270
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fatma Savran Oguz Lale Ocal Ali Sarper Diler Hilmi Ozkul Faruk Asicioglu Esen Kasapoglu Gokay Bozkurt Meral Konice Mahmut Carin
spellingShingle	Fatma Savran Oguz Lale Ocal Ali Sarper Diler Hilmi Ozkul Faruk Asicioglu Esen Kasapoglu Gokay Bozkurt Meral Konice Mahmut Carin HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls Disease Markers
author_facet	Fatma Savran Oguz Lale Ocal Ali Sarper Diler Hilmi Ozkul Faruk Asicioglu Esen Kasapoglu Gokay Bozkurt Meral Konice Mahmut Carin
author_sort	Fatma Savran Oguz
title	HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls
title_short	HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls
title_full	HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls
title_fullStr	HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls
title_full_unstemmed	HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls
title_sort	hla b-27 subtypes in turkish patients with spondyloarthropathy and healthy controls
publisher	Hindawi Limited
series	Disease Markers
issn	0278-0240 1875-8630
publishDate	2004-01-01
description	The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B∗27 was 2.6% in the Turkish population, and B∗2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B∗2705 among B27-positive patients and controls was significantly different (P = 0.02). Our study supports other reports from different populations which showed that B∗2705 and B∗2702 were more frequent in Caucasian patients with SpA.
url	http://dx.doi.org/10.1155/2004/565270
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HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls

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