Anticancer Activity of Green Tea Polyphenols in Prostate Gland
Numerous evidences from prevention studies in humans, support the existence of an association between green tea polyphenols consumption and a reduced cancer risk. Prostate cancer is one of the most frequently diagnosed male neoplasia in the Western countries, which is in agreement with this gland be...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2012-01-01
|
Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2012/984219 |
id |
doaj-ca02a09cd263443bb222b5c9f2dd7aeb |
---|---|
record_format |
Article |
spelling |
doaj-ca02a09cd263443bb222b5c9f2dd7aeb2020-11-24T21:28:37ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942012-01-01201210.1155/2012/984219984219Anticancer Activity of Green Tea Polyphenols in Prostate GlandPierpaola Davalli0Federica Rizzi1Andrea Caporali2Davide Pellacani3Serena Davoli4Saverio Bettuzzi5Maurizio Brausi6Domenico D’Arca7Department of Biomedical Sciences, University of Modena & Reggio Emilia, 41121 Modena, ItalyDepartment of Experimental Medicine, University of Parma, 43100 Parma, ItalyLaboratory of Vascular Pathology and Regeneration, Regenerative Medicine Section, School of Clinical Sciences, University of Bristol, Bristol BS2 8AE, UKYCR Cancer Research Unit, Department of Biology, University of York, York YO10 5DD, UKInstitut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/UdS, 67404 Illkirch Cedex, Strasbourg, FranceDepartment of Experimental Medicine, University of Parma, 43100 Parma, ItalyDepartment of Urology B. Ramazzini Hospital, 41012 Carpi, ItalyDepartment of Biomedical Sciences, University of Modena & Reggio Emilia, 41121 Modena, ItalyNumerous evidences from prevention studies in humans, support the existence of an association between green tea polyphenols consumption and a reduced cancer risk. Prostate cancer is one of the most frequently diagnosed male neoplasia in the Western countries, which is in agreement with this gland being particularly vulnerable to oxidative stress processes, often associated with tumorigenesis. Tea polyphenols have been extensively studied in cell culture and animal models where they inhibited tumor onset and progression. Prostate cancer appears a suitable target for primary prevention care, since it grows slowly, before symptoms arise, thus offering a relatively long time period for therapeutic interventions. It is, in fact, usually diagnosed in men 50-year-old or older, when even a modest delay in progression of the disease could significantly improve the patients quality of life. Although epidemiological studies have not yet yielded conclusive results on the chemopreventive and anticancer effect of tea polyphenols, there is an increasing trend to employ these substances as conservative management for patients diagnosed with less advanced prostate cancer. Here, we intend to review the most recent observations relating tea polyphenols to human prostate cancer risk, in an attempt to outline better their potential employment for preventing prostate cancer.http://dx.doi.org/10.1155/2012/984219 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pierpaola Davalli Federica Rizzi Andrea Caporali Davide Pellacani Serena Davoli Saverio Bettuzzi Maurizio Brausi Domenico D’Arca |
spellingShingle |
Pierpaola Davalli Federica Rizzi Andrea Caporali Davide Pellacani Serena Davoli Saverio Bettuzzi Maurizio Brausi Domenico D’Arca Anticancer Activity of Green Tea Polyphenols in Prostate Gland Oxidative Medicine and Cellular Longevity |
author_facet |
Pierpaola Davalli Federica Rizzi Andrea Caporali Davide Pellacani Serena Davoli Saverio Bettuzzi Maurizio Brausi Domenico D’Arca |
author_sort |
Pierpaola Davalli |
title |
Anticancer Activity of Green Tea Polyphenols in Prostate Gland |
title_short |
Anticancer Activity of Green Tea Polyphenols in Prostate Gland |
title_full |
Anticancer Activity of Green Tea Polyphenols in Prostate Gland |
title_fullStr |
Anticancer Activity of Green Tea Polyphenols in Prostate Gland |
title_full_unstemmed |
Anticancer Activity of Green Tea Polyphenols in Prostate Gland |
title_sort |
anticancer activity of green tea polyphenols in prostate gland |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2012-01-01 |
description |
Numerous evidences from prevention studies in humans, support the existence of an association between green tea polyphenols consumption and a reduced cancer risk. Prostate cancer is one of the most frequently diagnosed male neoplasia in the Western countries, which is in agreement with this gland being particularly vulnerable to oxidative stress processes, often associated with tumorigenesis. Tea polyphenols have been extensively studied in cell culture and animal models where they inhibited tumor onset and progression. Prostate cancer appears a suitable target for primary prevention care, since it grows slowly, before symptoms arise, thus offering a relatively long time period for therapeutic interventions. It is, in fact, usually diagnosed in men 50-year-old or older, when even a modest delay in progression of the disease could significantly improve the patients quality of life. Although epidemiological studies have not yet yielded conclusive results on the chemopreventive and anticancer effect of tea polyphenols, there is an increasing trend to employ these substances as conservative management for patients diagnosed with less advanced prostate cancer. Here, we intend to review the most recent observations relating tea polyphenols to human prostate cancer risk, in an attempt to outline better their potential employment for preventing prostate cancer. |
url |
http://dx.doi.org/10.1155/2012/984219 |
work_keys_str_mv |
AT pierpaoladavalli anticanceractivityofgreenteapolyphenolsinprostategland AT federicarizzi anticanceractivityofgreenteapolyphenolsinprostategland AT andreacaporali anticanceractivityofgreenteapolyphenolsinprostategland AT davidepellacani anticanceractivityofgreenteapolyphenolsinprostategland AT serenadavoli anticanceractivityofgreenteapolyphenolsinprostategland AT saveriobettuzzi anticanceractivityofgreenteapolyphenolsinprostategland AT mauriziobrausi anticanceractivityofgreenteapolyphenolsinprostategland AT domenicodarca anticanceractivityofgreenteapolyphenolsinprostategland |
_version_ |
1725969431106945024 |