Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins.
Longitudinal studies were carried out in the rabbit model to determine alterations in the concentration and density distribution of plasma lipids and apolipoproteins during the acute phase response (APR) characterized by elevated levels of C-reactive protein (CRP) and serum amyloid A (SAA). Twelve h...
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1989-01-01
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doaj-ca06fd2cc86341ce9df3c3e65329343d2021-04-25T04:18:55ZengElsevierJournal of Lipid Research0022-22751989-01-013013949Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins.V G Cabana0J N Siegel1S M Sabesin2Department of Medicine, University of Chicago, IL 60637.Department of Medicine, University of Chicago, IL 60637.Department of Medicine, University of Chicago, IL 60637.Longitudinal studies were carried out in the rabbit model to determine alterations in the concentration and density distribution of plasma lipids and apolipoproteins during the acute phase response (APR) characterized by elevated levels of C-reactive protein (CRP) and serum amyloid A (SAA). Twelve hr after the intramuscular injection of croton oil, SAA was detectable in high density lipoprotein (HDL). At the height of the response (72 hr), HDL decreased while SAA became the major HDL apoprotein, up to 80% of the proteins in the higher density fractions. The SAA-enriched particles became denser (density of HDL3) but larger (size of HDL2), had slower electrophoretic mobility, and were depleted in apoA-I, cholesterol, triglyceride, and phospholipid. HDL-cholesterol decreased and was redistributed to other fractions while apoA-I disappeared from the circulation. During this time plasma triglycerides increased 6- to 10-fold while plasma cholesterol and phospholipids showed minimal changes. ApoB increased 5- to 6-fold while the apoB-containing particles shifted to higher density resulting in elevated IDL and then LDL during recovery. VLDL (d less than 1.006 g/ml) increased and acquired 30-40% of the plasma triglycerides, cholesterol, phospholipid, and apoB. SAA also increased in VLDL while apoE decreased.http://www.sciencedirect.com/science/article/pii/S0022227520383905 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
V G Cabana J N Siegel S M Sabesin |
spellingShingle |
V G Cabana J N Siegel S M Sabesin Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. Journal of Lipid Research |
author_facet |
V G Cabana J N Siegel S M Sabesin |
author_sort |
V G Cabana |
title |
Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. |
title_short |
Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. |
title_full |
Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. |
title_fullStr |
Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. |
title_full_unstemmed |
Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. |
title_sort |
effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
1989-01-01 |
description |
Longitudinal studies were carried out in the rabbit model to determine alterations in the concentration and density distribution of plasma lipids and apolipoproteins during the acute phase response (APR) characterized by elevated levels of C-reactive protein (CRP) and serum amyloid A (SAA). Twelve hr after the intramuscular injection of croton oil, SAA was detectable in high density lipoprotein (HDL). At the height of the response (72 hr), HDL decreased while SAA became the major HDL apoprotein, up to 80% of the proteins in the higher density fractions. The SAA-enriched particles became denser (density of HDL3) but larger (size of HDL2), had slower electrophoretic mobility, and were depleted in apoA-I, cholesterol, triglyceride, and phospholipid. HDL-cholesterol decreased and was redistributed to other fractions while apoA-I disappeared from the circulation. During this time plasma triglycerides increased 6- to 10-fold while plasma cholesterol and phospholipids showed minimal changes. ApoB increased 5- to 6-fold while the apoB-containing particles shifted to higher density resulting in elevated IDL and then LDL during recovery. VLDL (d less than 1.006 g/ml) increased and acquired 30-40% of the plasma triglycerides, cholesterol, phospholipid, and apoB. SAA also increased in VLDL while apoE decreased. |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520383905 |
work_keys_str_mv |
AT vgcabana effectsoftheacutephaseresponseontheconcentrationanddensitydistributionofplasmalipidsandapolipoproteins AT jnsiegel effectsoftheacutephaseresponseontheconcentrationanddensitydistributionofplasmalipidsandapolipoproteins AT smsabesin effectsoftheacutephaseresponseontheconcentrationanddensitydistributionofplasmalipidsandapolipoproteins |
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