Phospholipids of the Plasma Membrane – Regulators or Consequence of Cell Polarity?
Cell polarity is a key feature of many eukaryotic cells, including neurons, epithelia, endothelia and asymmetrically dividing stem cells. Apart from the specific localization of proteins to distinct domains of the plasma membrane, most of these cells exhibit an asymmetric distribution of phospholipi...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-04-01
|
Series: | Frontiers in Cell and Developmental Biology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.00277/full |
id |
doaj-ca0b0ba292ee493e854b8de0c0a6efc6 |
---|---|
record_format |
Article |
spelling |
doaj-ca0b0ba292ee493e854b8de0c0a6efc62020-11-25T02:33:28ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-04-01810.3389/fcell.2020.00277531047Phospholipids of the Plasma Membrane – Regulators or Consequence of Cell Polarity?Michael P. KrahnCell polarity is a key feature of many eukaryotic cells, including neurons, epithelia, endothelia and asymmetrically dividing stem cells. Apart from the specific localization of proteins to distinct domains of the plasma membrane, most of these cells exhibit an asymmetric distribution of phospholipids within the plasma membrane too. Notably, research over the last years has revealed that many known conserved regulators of apical-basal polarity in epithelial cells are capable of binding to phospholipids, which in turn regulate the localization and to some extent the function of these proteins. Conversely, phospholipid-modifying enzymes are recruited and controlled by polarity regulators, demonstrating an elaborated balance between asymmetrically localized proteins and phospholipids, which are enriched in certain (micro)domains of the plasma membrane. In this review, we will focus on our current understanding of apical-basal polarity and the implication of phospholipids within the plasma membrane during the cell polarization of epithelia and migrating cells.https://www.frontiersin.org/article/10.3389/fcell.2020.00277/fullcell polarityphospholipidsphosphoinositidephosphatidic acidplasma membrane |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael P. Krahn |
spellingShingle |
Michael P. Krahn Phospholipids of the Plasma Membrane – Regulators or Consequence of Cell Polarity? Frontiers in Cell and Developmental Biology cell polarity phospholipids phosphoinositide phosphatidic acid plasma membrane |
author_facet |
Michael P. Krahn |
author_sort |
Michael P. Krahn |
title |
Phospholipids of the Plasma Membrane – Regulators or Consequence of Cell Polarity? |
title_short |
Phospholipids of the Plasma Membrane – Regulators or Consequence of Cell Polarity? |
title_full |
Phospholipids of the Plasma Membrane – Regulators or Consequence of Cell Polarity? |
title_fullStr |
Phospholipids of the Plasma Membrane – Regulators or Consequence of Cell Polarity? |
title_full_unstemmed |
Phospholipids of the Plasma Membrane – Regulators or Consequence of Cell Polarity? |
title_sort |
phospholipids of the plasma membrane – regulators or consequence of cell polarity? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-04-01 |
description |
Cell polarity is a key feature of many eukaryotic cells, including neurons, epithelia, endothelia and asymmetrically dividing stem cells. Apart from the specific localization of proteins to distinct domains of the plasma membrane, most of these cells exhibit an asymmetric distribution of phospholipids within the plasma membrane too. Notably, research over the last years has revealed that many known conserved regulators of apical-basal polarity in epithelial cells are capable of binding to phospholipids, which in turn regulate the localization and to some extent the function of these proteins. Conversely, phospholipid-modifying enzymes are recruited and controlled by polarity regulators, demonstrating an elaborated balance between asymmetrically localized proteins and phospholipids, which are enriched in certain (micro)domains of the plasma membrane. In this review, we will focus on our current understanding of apical-basal polarity and the implication of phospholipids within the plasma membrane during the cell polarization of epithelia and migrating cells. |
topic |
cell polarity phospholipids phosphoinositide phosphatidic acid plasma membrane |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00277/full |
work_keys_str_mv |
AT michaelpkrahn phospholipidsoftheplasmamembraneregulatorsorconsequenceofcellpolarity |
_version_ |
1724813970755289088 |