Noggin Overexpression Impairs the Development of Muscles, Tendons, and Aponeurosis in Soft Palates by Disrupting BMP-Smad and Shh-Gli1 Signaling

Noggin Overexpression Impairs the Development of Muscles, Tendons, and Aponeurosis in Soft Palates by Disrupting BMP-Smad and Shh-Gli1 Signaling

The roles of bone morphogenetic protein (BMP) signaling in palatogenesis were well documented in the developing hard palate; however, little is known about how BMP signaling regulates the development of soft palate. In this study, we overexpressed Noggin transgene via Osr2-creKI allele to suppress B...

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Bibliographic Details
Main Authors: Jiamin Deng, Shangqi Wang, Nan Li, Xiaoyan Chen, Biying Wang, Han Liu, Lei Zhu, Wei Cong, Jing Xiao, Chao Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
palatogenesis
cleft soft palate
BMP signaling
aponeurosis
myogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.711334/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.711334/full

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