The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population
Objective. To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. Methods. Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and...
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2016-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2016/7089137 |
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doaj-ca13f43dbeac4438a9f00c9921f23edb2020-11-24T21:04:47ZengHindawi LimitedMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/70891377089137The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han PopulationYang Gong0Yifan Lin1Ning Zhao2Xiaojuan He3Aiping Lu4Wei Wei5Miao Jiang6The General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, ChinaThe General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaBeijing Wangjing Hospital, Beijing University of Chinese Medicine, Beijing 100102, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaObjective. To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. Methods. Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in peripheral blood was determined with flow cytometry. Results. In UC patients, the levels of IL-17 and Th17 were significantly higher compared with healthy subjects; the percentage of Th17 and IL-17 level in moderate and severe subgroup was significantly higher than in mild subgroup; a positive correlation existed between these two indexes and clinical activity index and endoscopic evaluation. TGF-β1 level and Treg cells in UC patients were lower than healthy subjects. TGF-β1 level in moderate and severe subgroup was lower than in mild subgroup. There was a negative linear correlation between Treg cells and clinical activity index, endoscopic evaluation. A positive correlation was detected between Treg cells and TGF-β1 level. Conclusions. Th17/Treg immune imbalance might play a crucial role in the development of UC. To induce the production of Treg cells and TGF-β1, inhibit the level of Th17 and IL-17, and thus recover the Th17/Treg immune balance might imply new therapeutic targets in UC management.http://dx.doi.org/10.1155/2016/7089137 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang Gong Yifan Lin Ning Zhao Xiaojuan He Aiping Lu Wei Wei Miao Jiang |
spellingShingle |
Yang Gong Yifan Lin Ning Zhao Xiaojuan He Aiping Lu Wei Wei Miao Jiang The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population Mediators of Inflammation |
author_facet |
Yang Gong Yifan Lin Ning Zhao Xiaojuan He Aiping Lu Wei Wei Miao Jiang |
author_sort |
Yang Gong |
title |
The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population |
title_short |
The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population |
title_full |
The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population |
title_fullStr |
The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population |
title_full_unstemmed |
The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population |
title_sort |
th17/treg immune imbalance in ulcerative colitis disease in a chinese han population |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2016-01-01 |
description |
Objective. To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. Methods. Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in peripheral blood was determined with flow cytometry. Results. In UC patients, the levels of IL-17 and Th17 were significantly higher compared with healthy subjects; the percentage of Th17 and IL-17 level in moderate and severe subgroup was significantly higher than in mild subgroup; a positive correlation existed between these two indexes and clinical activity index and endoscopic evaluation. TGF-β1 level and Treg cells in UC patients were lower than healthy subjects. TGF-β1 level in moderate and severe subgroup was lower than in mild subgroup. There was a negative linear correlation between Treg cells and clinical activity index, endoscopic evaluation. A positive correlation was detected between Treg cells and TGF-β1 level. Conclusions. Th17/Treg immune imbalance might play a crucial role in the development of UC. To induce the production of Treg cells and TGF-β1, inhibit the level of Th17 and IL-17, and thus recover the Th17/Treg immune balance might imply new therapeutic targets in UC management. |
url |
http://dx.doi.org/10.1155/2016/7089137 |
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