Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice

• Main Authors: Akihisa Takahashi, Shoto Wakihata, Liqiu Ma, Takuya Adachi, Hiroki Hirose, Yukari Yoshida, Yoshinobu Ohira
• Format: Article
• Language: English
• Published: MDPI AG 2018-12-01
• Series: International Journal of Molecular Sciences
• Subjects: tumor growth; metastasis; immune system; hind-limb unloading; animal model
• Online Access: https://www.mdpi.com/1422-0067/19/12/3959

Although the body&#8217;s immune system is altered during spaceflight, the effects of microgravity (&#956;<i>G</i>) on tumor growth and carcinogenesis are, as yet, unknown. To assess tumor proliferation and its effects on the immune system, we used a hind-limb unloading (HU) murine model to simulate &#956;<i>G</i> during spaceflight. HU mice demonstrated significantly increased tumor growth, metastasis to the lung, and greater splenic and thymic atrophy compared with mice in constant orthostatic suspension and standard housing controls. In addition, mice undergoing temporary loading during HU (2 h per day) demonstrated no difference in cancer progression and immune organ atrophy compared with controls. Our findings suggest that temporary loading can prevent cancer progression and immune organ atrophy induced by HU. Further space experiment studies are warranted to elucidate the precise effects of &#956;<i>G</i> on systemic immunity and cancer progression.