New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective
Glioblastoma multiforme (GBM) is the most common tumor of the CNS, and the deadliest form of brain cancer. The rapid progression, the anatomic location in the brain and a deficient knowledge of the pathophysiology, often limit the effectiveness of therapeutic interventions. Current pillars of GBM th...
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doaj-ca2474d837b24f28945e1ab9c742e7da2020-11-24T22:19:42ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-08-01910.3389/fphar.2018.00874388950New Multitarget Approaches in the War Against Glioblastoma: A Mini-PerspectiveSimona Sestito0Massimiliano Runfola1Marco Tonelli2Grazia Chiellini3Simona Rapposelli4Simona Rapposelli5Department of Pharmacy, University of Pisa, Pisa, ItalyDepartment of Pharmacy, University of Pisa, Pisa, ItalyBiochemistry Department, University of Wisconsin-Madison, Madison, WI, United StatesDepartment of Pathology, University of Pisa, Pisa, ItalyDepartment of Pharmacy, University of Pisa, Pisa, ItalyInterdepartmental Research Centre for Biology and Pathology of Aging, University of Pisa, Pisa, ItalyGlioblastoma multiforme (GBM) is the most common tumor of the CNS, and the deadliest form of brain cancer. The rapid progression, the anatomic location in the brain and a deficient knowledge of the pathophysiology, often limit the effectiveness of therapeutic interventions. Current pillars of GBM therapies include surgical resection, radiotherapy and chemotherapy, but the low survival rate and the short life expectation following these treatments strongly underline the urgency to identify innovative and more effective therapeutic tools. Frequently, patients subjected to a mono-target therapy, such as Temozolomide (TMZ), develop drug resistance and undergo relapse, indicating that targeting a single cellular node is not sufficient for eradication of this disease. In this context, a multi-targeted therapeutic approach aimed at using compounds, alone or in combination, capable of inhibiting more than one specific molecular target, offers a promising alternative. Such strategies have already been well integrated into drug discovery campaigns, including in the field of anticancer drugs. In this miniperspective, we will discuss the recent progress in the treatment of GBM focusing on innovative and effective preclinical strategies, which are based on a multi-targeted approach.https://www.frontiersin.org/article/10.3389/fphar.2018.00874/fullglioblastomamultitarget drugmultiple kinase inhibitorsmall moleculescombination therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Simona Sestito Massimiliano Runfola Marco Tonelli Grazia Chiellini Simona Rapposelli Simona Rapposelli |
spellingShingle |
Simona Sestito Massimiliano Runfola Marco Tonelli Grazia Chiellini Simona Rapposelli Simona Rapposelli New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective Frontiers in Pharmacology glioblastoma multitarget drug multiple kinase inhibitor small molecules combination therapy |
author_facet |
Simona Sestito Massimiliano Runfola Marco Tonelli Grazia Chiellini Simona Rapposelli Simona Rapposelli |
author_sort |
Simona Sestito |
title |
New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective |
title_short |
New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective |
title_full |
New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective |
title_fullStr |
New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective |
title_full_unstemmed |
New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective |
title_sort |
new multitarget approaches in the war against glioblastoma: a mini-perspective |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2018-08-01 |
description |
Glioblastoma multiforme (GBM) is the most common tumor of the CNS, and the deadliest form of brain cancer. The rapid progression, the anatomic location in the brain and a deficient knowledge of the pathophysiology, often limit the effectiveness of therapeutic interventions. Current pillars of GBM therapies include surgical resection, radiotherapy and chemotherapy, but the low survival rate and the short life expectation following these treatments strongly underline the urgency to identify innovative and more effective therapeutic tools. Frequently, patients subjected to a mono-target therapy, such as Temozolomide (TMZ), develop drug resistance and undergo relapse, indicating that targeting a single cellular node is not sufficient for eradication of this disease. In this context, a multi-targeted therapeutic approach aimed at using compounds, alone or in combination, capable of inhibiting more than one specific molecular target, offers a promising alternative. Such strategies have already been well integrated into drug discovery campaigns, including in the field of anticancer drugs. In this miniperspective, we will discuss the recent progress in the treatment of GBM focusing on innovative and effective preclinical strategies, which are based on a multi-targeted approach. |
topic |
glioblastoma multitarget drug multiple kinase inhibitor small molecules combination therapy |
url |
https://www.frontiersin.org/article/10.3389/fphar.2018.00874/full |
work_keys_str_mv |
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