Effects of laparoscopic hepatectomy and open hepatectomy on liver function

• Main Authors: Shi-Bu Lin, Yan Yang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-11-01
• Series: Journal of Hainan Medical University
• Subjects: hepatectomy; laparoscopy; laparotomy; liver function; comparative study
• Online Access: http://www.hnykdxxb.com/PDF/201911/10.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To assess the effects of laparoscopic hepatectomy (LH) and open hepatectomy (OH) on liver function of patients. Methods: From July 2016 to December 2017 in our hospital, a total 47 cases of patients match the inclusion and exclusion standards, were divided into laparoscopic hepatectomy (LH group, 51) and open hepatectomy (OH group, 59) randomly. Data of pre- and post-operative liver function of two groups were compared. Results: On the first, second and third day after surgery, the postoperative medians value of ALT in LH group was significantly reduced than in OH group (113.98U/L vs 133.30U/L，Z=-2.086， P=0.037；97.55U/L vs 189.50U/L，Z=-2.341，P=0.019；62.66U/L vs 109.20U/L，Z=- 2.171，P=0.030). Meanwhile, the value of AST in LH group was significantly lower than in OH group (75.70U/L vs 141.00U/L，Z=-2.245，P=0.025；61.25U/L vs 147.20U/L，Z=- 3.193，P=0.001；30.85U/L vs 51.20U/L，Z=-2.331，P=0.020). However, the differences of aminotransferase were not statistically significant in two groups on the seventh day after surgery (P>0.05). The degree of elevations of TBIL, DBIL and PT were remarkably lower in LH group than OH group (P<0.05), as well as, all of index recovered in LH group faster than in OH group. Conclusions: Compared with OH, the effects of LH on liver function in patients are lesser, and LH is beneficial for recovery of patients after hepatectomy.