New binding mode to TNF-alpha revealed by ubiquitin-based artificial binding protein.

New binding mode to TNF-alpha revealed by ubiquitin-based artificial binding protein.

A variety of approaches have been employed to generate binding proteins from non-antibody scaffolds. Utilizing a beta-sheet of the human ubiquitin for paratope creation we obtained binding proteins against tumor necrosis factor (TNF)-alpha. The bioactive form of this validated pharmacological target...

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Bibliographic Details
Main Authors: Andreas Hoffmann, Michael Kovermann, Hauke Lilie, Markus Fiedler, Jochen Balbach, Rainer Rudolph, Sven Pfeifer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3282696?pdf=render

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