TSLP and Immune Homeostasis
In an immune system, dendritic cells (DCs) are professional antigen-presenting cells (APCs) as well as powerful sensors of danger signals. When DCs receive signals from infection and tissue stress, they immediately activate and instruct the initiation of appropriate immune responses to T cells. Howe...
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doaj-ca45dec9807a4034a13dff4aef14f9f72020-11-24T21:01:33ZengElsevierAllergology International1323-89302012-01-01611192510.2332/allergolint.11-RAI-0394TSLP and Immune HomeostasisShino Hanabuchi0Norihiko Watanabe1Yong-Jun Liu2Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, HoustonDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, HoustonIn an immune system, dendritic cells (DCs) are professional antigen-presenting cells (APCs) as well as powerful sensors of danger signals. When DCs receive signals from infection and tissue stress, they immediately activate and instruct the initiation of appropriate immune responses to T cells. However, it has remained unclear how the tissue microenvironment in a steady state shapes the function of DCs. Recent many works on thymic stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine that has the strong ability to activate DCs, provide evidence that TSLP mediates crosstalk between epithelial cells and DCs, involving in DC-mediated immune homeostasis. Here, we review recent progress made on how TSLP expressed within the thymus and peripheral lymphoid and non-lymphoid tissues regulates DC-mediated T-cell development in the thymus and T-cell homeostasis in the periphery.http://www.sciencedirect.com/science/article/pii/S1323893015301891DC (Dendritic cell)homeostasisregulatory T cellthymusTSLP |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shino Hanabuchi Norihiko Watanabe Yong-Jun Liu |
spellingShingle |
Shino Hanabuchi Norihiko Watanabe Yong-Jun Liu TSLP and Immune Homeostasis Allergology International DC (Dendritic cell) homeostasis regulatory T cell thymus TSLP |
author_facet |
Shino Hanabuchi Norihiko Watanabe Yong-Jun Liu |
author_sort |
Shino Hanabuchi |
title |
TSLP and Immune Homeostasis |
title_short |
TSLP and Immune Homeostasis |
title_full |
TSLP and Immune Homeostasis |
title_fullStr |
TSLP and Immune Homeostasis |
title_full_unstemmed |
TSLP and Immune Homeostasis |
title_sort |
tslp and immune homeostasis |
publisher |
Elsevier |
series |
Allergology International |
issn |
1323-8930 |
publishDate |
2012-01-01 |
description |
In an immune system, dendritic cells (DCs) are professional antigen-presenting cells (APCs) as well as powerful sensors of danger signals. When DCs receive signals from infection and tissue stress, they immediately activate and instruct the initiation of appropriate immune responses to T cells. However, it has remained unclear how the tissue microenvironment in a steady state shapes the function of DCs. Recent many works on thymic stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine that has the strong ability to activate DCs, provide evidence that TSLP mediates crosstalk between epithelial cells and DCs, involving in DC-mediated immune homeostasis. Here, we review recent progress made on how TSLP expressed within the thymus and peripheral lymphoid and non-lymphoid tissues regulates DC-mediated T-cell development in the thymus and T-cell homeostasis in the periphery. |
topic |
DC (Dendritic cell) homeostasis regulatory T cell thymus TSLP |
url |
http://www.sciencedirect.com/science/article/pii/S1323893015301891 |
work_keys_str_mv |
AT shinohanabuchi tslpandimmunehomeostasis AT norihikowatanabe tslpandimmunehomeostasis AT yongjunliu tslpandimmunehomeostasis |
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1716777661069524992 |