A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae)
Neoglaziovia variegata is endemic to northeastern Brazil. The drought resistant plant produces edible fruits and is used as a fibre plant by rural communities in the Caatinga region where a variety of products are made from the white, soft and flexible fibres. Extracts of N. variegata have been repo...
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doaj-ca4812726ac94f38ae5e9ccc0b1033c52020-11-25T02:56:36ZengElsevierHeliyon2405-84402019-03-0153e01369A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae)Ayaan Hamdi Haji Ibrahim0Lars Herfindal1Bendik Rathe2Heidi Lie Andersen3Jackson Roberto Guedes da Silva Almeida4Torgils Fossen5Department of Chemistry and Centre for Pharmacy, University of Bergen, Allégt. 41, N-5007 Bergen, NorwayDepartment of Clinical Science and Centre for Pharmacy, University of Bergen; Hospital Pharmacies Enterprise, Western Norway, Bergen, NorwayDepartment of Chemistry and Centre for Pharmacy, University of Bergen, Allégt. 41, N-5007 Bergen, Norway; Department of Clinical Science and Centre for Pharmacy, University of BergenArboretum and Botanical Gardens, University of Bergen, Allégaten 41, 5007 Bergen, NorwayCentre for Studies and Research of Medicinal Plants, Federal University of Vale do São Francisco, 56.304-205 Petrolina, Pernambuco, BrazilDepartment of Chemistry and Centre for Pharmacy, University of Bergen, Allégt. 41, N-5007 Bergen, Norway; Corresponding author.Neoglaziovia variegata is endemic to northeastern Brazil. The drought resistant plant produces edible fruits and is used as a fibre plant by rural communities in the Caatinga region where a variety of products are made from the white, soft and flexible fibres. Extracts of N. variegata have been reported to be of low toxicity and to exhibit antinociceptive effect, photoprotective potential, antioxidant effect, gastroprotective effects and antibacterial effect against both Gram-positive and Gram-negative bacteria, however, the chemical constituents of this species are mainly unknown. The novel poly-oxygenated flavone glucoside 5,6,7,4'-tetrahydroxy-3',5'-dimethoxy-flavone 7-O-β-glucopyranoside in addition to the rare poly-oxygenated flavone 5,4'-dihydroxy-6,7,3'-trimethoxyflavone 4'-O-β-glucopyranoside and the flavonol quercetin 3-O-(6''-rhamnopyranosyl-β-glucopyranoside) have been characterised from the leaves of N. variegata. 5,6,7,4'-tetrahydroxy-3',5'-dimethoxy-flavone, which comprises the core structure of the novel compound, is a new flavonoid aglycone in nature. The structure determinations were based on extensive use of 2D NMR spectroscopic techniques and high-resolution mass spectrometry. Both substances exhibited toxicity towards MOLM-13 acute myeloid leukaemia cells.http://www.sciencedirect.com/science/article/pii/S2405844018383294BiochemistryCell biologyFood analysisFood scienceMolecular biologyNatural product chemistry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ayaan Hamdi Haji Ibrahim Lars Herfindal Bendik Rathe Heidi Lie Andersen Jackson Roberto Guedes da Silva Almeida Torgils Fossen |
spellingShingle |
Ayaan Hamdi Haji Ibrahim Lars Herfindal Bendik Rathe Heidi Lie Andersen Jackson Roberto Guedes da Silva Almeida Torgils Fossen A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae) Heliyon Biochemistry Cell biology Food analysis Food science Molecular biology Natural product chemistry |
author_facet |
Ayaan Hamdi Haji Ibrahim Lars Herfindal Bendik Rathe Heidi Lie Andersen Jackson Roberto Guedes da Silva Almeida Torgils Fossen |
author_sort |
Ayaan Hamdi Haji Ibrahim |
title |
A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae) |
title_short |
A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae) |
title_full |
A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae) |
title_fullStr |
A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae) |
title_full_unstemmed |
A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae) |
title_sort |
novel poly-oxygenated flavone glucoside from aerial parts of the brazilian plant neoglaziovia variegata (bromeliaceae) |
publisher |
Elsevier |
series |
Heliyon |
issn |
2405-8440 |
publishDate |
2019-03-01 |
description |
Neoglaziovia variegata is endemic to northeastern Brazil. The drought resistant plant produces edible fruits and is used as a fibre plant by rural communities in the Caatinga region where a variety of products are made from the white, soft and flexible fibres. Extracts of N. variegata have been reported to be of low toxicity and to exhibit antinociceptive effect, photoprotective potential, antioxidant effect, gastroprotective effects and antibacterial effect against both Gram-positive and Gram-negative bacteria, however, the chemical constituents of this species are mainly unknown. The novel poly-oxygenated flavone glucoside 5,6,7,4'-tetrahydroxy-3',5'-dimethoxy-flavone 7-O-β-glucopyranoside in addition to the rare poly-oxygenated flavone 5,4'-dihydroxy-6,7,3'-trimethoxyflavone 4'-O-β-glucopyranoside and the flavonol quercetin 3-O-(6''-rhamnopyranosyl-β-glucopyranoside) have been characterised from the leaves of N. variegata. 5,6,7,4'-tetrahydroxy-3',5'-dimethoxy-flavone, which comprises the core structure of the novel compound, is a new flavonoid aglycone in nature. The structure determinations were based on extensive use of 2D NMR spectroscopic techniques and high-resolution mass spectrometry. Both substances exhibited toxicity towards MOLM-13 acute myeloid leukaemia cells. |
topic |
Biochemistry Cell biology Food analysis Food science Molecular biology Natural product chemistry |
url |
http://www.sciencedirect.com/science/article/pii/S2405844018383294 |
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