Neuroticism Modulates the Functional Connectivity From Amygdala to Frontal Networks in Females When Avoiding Emotional Negative Pictures
Amygdala activity was previously found to correlate with neuroticism as an effect of valence, but so far few studies have focused on motivational context. The network subserving altered amygdala activity has not yet been investigated although some studies showed strong effective connections with pre...
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doaj-ca6337a4c8124c2bb0e47fa2f1a6999b2020-11-24T21:21:34ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-05-011310.3389/fnbeh.2019.00102448353Neuroticism Modulates the Functional Connectivity From Amygdala to Frontal Networks in Females When Avoiding Emotional Negative PicturesYaling Deng0Shijia Li1Shijia Li2Renlai Zhou3Martin Walter4Martin Walter5Martin Walter6Martin Walter7Neuroscience and Intelligent Media Institute, Communication University of China, Beijing, ChinaKey Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, Shanghai, ChinaShanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, ChinaDepartment of Psychology, School of Social and Behavior Sciences, Nanjing University, Nanjing, ChinaDepartment of Psychiatry and Psychotherapy, Eberhard Karls University, Tübingen, GermanyMax Planck Institute for Biological Cybernetics, Tübingen, GermanyDepartment for Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, GermanyClinical Affective Neuroimaging Laboratory (CANLAB), Otto-von-Guericke University, Magdeburg, GermanyAmygdala activity was previously found to correlate with neuroticism as an effect of valence, but so far few studies have focused on motivational context. The network subserving altered amygdala activity has not yet been investigated although some studies showed strong effective connections with prefrontal cortex (PFC). The goal of this study was to test the modulatory role of neuroticism on the functional connectivity (FC) between amygdala and other brain regions, especially PFC, during emotion processing from motivational direction. We applied an emotional picture viewing paradigm with different motivational directions (approaching and avoiding) in a large participant sample. The results showed that neuroticism predicted the amount of amygdala FC to dorsomedial PFC (dmPFC) and middle cingulate cortex (MCC). Increased FC during negative vs. positive pictures was found primarily in low neuroticism subjects, especially during the avoid condition. This valence and motivation dependent connectivity increase were disrupted for high neurotic participants. No effect of neuroticism was found for the approach condition. We showed that neuroticism, especially in the context of passive affect regulation, may have impaired connectivity between amygdala and putative regulatory cortical networks.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00102/fullfunctional connectivityneuroticismmotivational directiondorsomedial prefrontal cortexmiddle cingulate cortex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yaling Deng Shijia Li Shijia Li Renlai Zhou Martin Walter Martin Walter Martin Walter Martin Walter |
spellingShingle |
Yaling Deng Shijia Li Shijia Li Renlai Zhou Martin Walter Martin Walter Martin Walter Martin Walter Neuroticism Modulates the Functional Connectivity From Amygdala to Frontal Networks in Females When Avoiding Emotional Negative Pictures Frontiers in Behavioral Neuroscience functional connectivity neuroticism motivational direction dorsomedial prefrontal cortex middle cingulate cortex |
author_facet |
Yaling Deng Shijia Li Shijia Li Renlai Zhou Martin Walter Martin Walter Martin Walter Martin Walter |
author_sort |
Yaling Deng |
title |
Neuroticism Modulates the Functional Connectivity From Amygdala to Frontal Networks in Females When Avoiding Emotional Negative Pictures |
title_short |
Neuroticism Modulates the Functional Connectivity From Amygdala to Frontal Networks in Females When Avoiding Emotional Negative Pictures |
title_full |
Neuroticism Modulates the Functional Connectivity From Amygdala to Frontal Networks in Females When Avoiding Emotional Negative Pictures |
title_fullStr |
Neuroticism Modulates the Functional Connectivity From Amygdala to Frontal Networks in Females When Avoiding Emotional Negative Pictures |
title_full_unstemmed |
Neuroticism Modulates the Functional Connectivity From Amygdala to Frontal Networks in Females When Avoiding Emotional Negative Pictures |
title_sort |
neuroticism modulates the functional connectivity from amygdala to frontal networks in females when avoiding emotional negative pictures |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2019-05-01 |
description |
Amygdala activity was previously found to correlate with neuroticism as an effect of valence, but so far few studies have focused on motivational context. The network subserving altered amygdala activity has not yet been investigated although some studies showed strong effective connections with prefrontal cortex (PFC). The goal of this study was to test the modulatory role of neuroticism on the functional connectivity (FC) between amygdala and other brain regions, especially PFC, during emotion processing from motivational direction. We applied an emotional picture viewing paradigm with different motivational directions (approaching and avoiding) in a large participant sample. The results showed that neuroticism predicted the amount of amygdala FC to dorsomedial PFC (dmPFC) and middle cingulate cortex (MCC). Increased FC during negative vs. positive pictures was found primarily in low neuroticism subjects, especially during the avoid condition. This valence and motivation dependent connectivity increase were disrupted for high neurotic participants. No effect of neuroticism was found for the approach condition. We showed that neuroticism, especially in the context of passive affect regulation, may have impaired connectivity between amygdala and putative regulatory cortical networks. |
topic |
functional connectivity neuroticism motivational direction dorsomedial prefrontal cortex middle cingulate cortex |
url |
https://www.frontiersin.org/article/10.3389/fnbeh.2019.00102/full |
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