A Mutant Library Approach to Identify Improved Meningococcal Factor H Binding Protein Vaccine Antigens.
Factor H binding protein (FHbp) is a virulence factor used by meningococci to evade the host complement system. FHbp elicits bactericidal antibodies in humans and is part of two recently licensed vaccines. Using human complement Factor H (FH) transgenic mice, we previously showed that binding of FH...
Main Authors: | Monica Konar, Raffaella Rossi, Helen Walter, Rolando Pajon, Peter T Beernink |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4461315?pdf=render |
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