Pandemic H1N1 influenza infection and vaccination in humans induces cross-protective antibodies that target the hemagglutinin stem

Pandemic H1N1 influenza infection and vaccination in humans induces cross-protective antibodies that target the hemagglutinin stem

Most monoclonal antibodies (mAbs) generated from humans infected or vaccinated with the 2009 pandemic H1N1 (pdmH1N1) influenza virus targeted the hemagglutinin (HA) stem. These anti-HA stem mAbs mostly used IGHV1-69 and bound readily to epitopes on the conventional seasonal influenza and pdmH1N1 vac...

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Bibliographic Details
Main Authors: Christy Ann Thomson, Yanni eWang, Linda eJackson, Melanie eOlson, Welson eWang, Alena eLiavonchanka, Liya eKeleta, Vanessa eSilva, Sandra eDiederich, R Brad Jones, Jonathan eGubbay, John ePasick, Martin ePetric, Francois eJean, Vanessa eAllen, Earl eBrown, James eRini, John William Schrader
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Immunology
Subjects:
Vaccines
competition for T cell help
cross-protective antibodies
hemagglutinin
heterosubtypic
memory B cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00087/full

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