Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity

Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity

Li et al. produce a dengue virus (DENV)-derived defective interfering particle (DIP) production cell line that can stably produce infectious virusfree DIPs. The DENV DIPs produced from this system can potently inhibit replication of all DENV serotypes in cells and have the potential to be repurposed...

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Bibliographic Details
Main Authors: Dongsheng Li, Min-Hsuan Lin, Daniel J. Rawle, Hongping Jin, Zhonglan Wu, Lu Wang, Mary Lor, Mazhar Hussain, John Aaskov, David Harrich
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02064-7
Description
Summary:Li et al. produce a dengue virus (DENV)-derived defective interfering particle (DIP) production cell line that can stably produce infectious virusfree DIPs. The DENV DIPs produced from this system can potently inhibit replication of all DENV serotypes in cells and have the potential to be repurposed to make antiviral DIPs for other RNA viruses.
ISSN:2399-3642

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