Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity

Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity

Li et al. produce a dengue virus (DENV)-derived defective interfering particle (DIP) production cell line that can stably produce infectious virusfree DIPs. The DENV DIPs produced from this system can potently inhibit replication of all DENV serotypes in cells and have the potential to be repurposed...

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Main Authors: Dongsheng Li, Min-Hsuan Lin, Daniel J. Rawle, Hongping Jin, Zhonglan Wu, Lu Wang, Mary Lor, Mazhar Hussain, John Aaskov, David Harrich
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02064-7
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spelling doaj-ca6d677537e941f587164eee3d3acebc2021-05-11T14:54:47ZengNature Publishing GroupCommunications Biology2399-36422021-05-014111110.1038/s42003-021-02064-7Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activityDongsheng Li0Min-Hsuan Lin1Daniel J. Rawle2Hongping Jin3Zhonglan Wu4Lu Wang5Mary Lor6Mazhar Hussain7John Aaskov8David Harrich9Department of Cell and Molecular Biology, QIMR Berghofer Medical Research InstituteDepartment of Cell and Molecular Biology, QIMR Berghofer Medical Research InstituteDepartment of Cell and Molecular Biology, QIMR Berghofer Medical Research InstituteDepartment of Cell and Molecular Biology, QIMR Berghofer Medical Research InstituteNingxia Center for Disease Control and PreventionDepartment of Cell and Molecular Biology, QIMR Berghofer Medical Research InstituteDepartment of Cell and Molecular Biology, QIMR Berghofer Medical Research InstituteInstitute of Health and Biomedical Innovation, Queensland University of TechnologyInstitute of Health and Biomedical Innovation, Queensland University of TechnologyDepartment of Cell and Molecular Biology, QIMR Berghofer Medical Research InstituteLi et al. produce a dengue virus (DENV)-derived defective interfering particle (DIP) production cell line that can stably produce infectious virusfree DIPs. The DENV DIPs produced from this system can potently inhibit replication of all DENV serotypes in cells and have the potential to be repurposed to make antiviral DIPs for other RNA viruses.https://doi.org/10.1038/s42003-021-02064-7
collection DOAJ
language English
format Article
sources DOAJ
author Dongsheng Li
Min-Hsuan Lin
Daniel J. Rawle
Hongping Jin
Zhonglan Wu
Lu Wang
Mary Lor
Mazhar Hussain
John Aaskov
David Harrich
spellingShingle Dongsheng Li
Min-Hsuan Lin
Daniel J. Rawle
Hongping Jin
Zhonglan Wu
Lu Wang
Mary Lor
Mazhar Hussain
John Aaskov
David Harrich
Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
Communications Biology
author_facet Dongsheng Li
Min-Hsuan Lin
Daniel J. Rawle
Hongping Jin
Zhonglan Wu
Lu Wang
Mary Lor
Mazhar Hussain
John Aaskov
David Harrich
author_sort Dongsheng Li
title Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
title_short Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
title_full Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
title_fullStr Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
title_full_unstemmed Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
title_sort dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-05-01
description Li et al. produce a dengue virus (DENV)-derived defective interfering particle (DIP) production cell line that can stably produce infectious virusfree DIPs. The DENV DIPs produced from this system can potently inhibit replication of all DENV serotypes in cells and have the potential to be repurposed to make antiviral DIPs for other RNA viruses.
url https://doi.org/10.1038/s42003-021-02064-7
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AT minhsuanlin denguevirusfreedefectiveinterferingparticleshavepotentandbroadantidenguevirusactivity
AT danieljrawle denguevirusfreedefectiveinterferingparticleshavepotentandbroadantidenguevirusactivity
AT hongpingjin denguevirusfreedefectiveinterferingparticleshavepotentandbroadantidenguevirusactivity
AT zhonglanwu denguevirusfreedefectiveinterferingparticleshavepotentandbroadantidenguevirusactivity
AT luwang denguevirusfreedefectiveinterferingparticleshavepotentandbroadantidenguevirusactivity
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AT mazharhussain denguevirusfreedefectiveinterferingparticleshavepotentandbroadantidenguevirusactivity
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