Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015
Background: Solid dispersions are an effective formulation technique to improve the solubility, dissolution rate, and bioavailability of water-insoluble drugs for oral delivery. In the last 15 years, increased attention was focused on this technology. There were 23 marketed drugs prepared by solid d...
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doaj-ca6e807fe75a43f8a8aa42a22b2d5e2b2020-11-25T00:45:26ZengMDPI AGMolecules1420-30492018-07-01237169710.3390/molecules23071697molecules23071697Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015Jinglu Zhang0Run Han1Weijie Chen2Weixiang Zhang3Ying Li4Yuanhui Ji5Lijiang Chen6Hao Pan7Xinggang Yang8Weisan Pan9Defang Ouyang10State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau 999078, ChinaDepartment of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, ChinaJiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, ChinaSchool of Pharmacy, Liaoning University, Shenyang 110000, ChinaSchool of Pharmacy, Liaoning University, Shenyang 110000, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110000, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110000, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau 999078, ChinaBackground: Solid dispersions are an effective formulation technique to improve the solubility, dissolution rate, and bioavailability of water-insoluble drugs for oral delivery. In the last 15 years, increased attention was focused on this technology. There were 23 marketed drugs prepared by solid dispersion techniques. Objective: This study aimed to report the big picture of solid dispersion research from 1980 to 2015. Method: Scientific knowledge mapping tools were used for the qualitative and the quantitative analysis of patents and literature from the time and space dimensions. Results: Western Europe and North America were the major research areas in this field with frequent international cooperation. Moreover, there was a close collaboration between universities and industries, while research collaboration in Asia mainly existed between universities. The model drugs, main excipients, preparation technologies, characterization approaches and the mechanism involved in the formulation of solid dispersions were analyzed via the keyword burst and co-citation cluster techniques. Integrated experimental, theoretical and computational tools were useful techniques for in silico formulation design of the solid dispersions. Conclusions: Our research provided the qualitative and the quantitative analysis of patents and literature of solid dispersions in the last three decades.http://www.mdpi.com/1420-3049/23/7/1697solid dispersionbig dataliteraturepatentscientific knowledge mappingCiteSpace |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinglu Zhang Run Han Weijie Chen Weixiang Zhang Ying Li Yuanhui Ji Lijiang Chen Hao Pan Xinggang Yang Weisan Pan Defang Ouyang |
spellingShingle |
Jinglu Zhang Run Han Weijie Chen Weixiang Zhang Ying Li Yuanhui Ji Lijiang Chen Hao Pan Xinggang Yang Weisan Pan Defang Ouyang Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015 Molecules solid dispersion big data literature patent scientific knowledge mapping CiteSpace |
author_facet |
Jinglu Zhang Run Han Weijie Chen Weixiang Zhang Ying Li Yuanhui Ji Lijiang Chen Hao Pan Xinggang Yang Weisan Pan Defang Ouyang |
author_sort |
Jinglu Zhang |
title |
Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015 |
title_short |
Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015 |
title_full |
Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015 |
title_fullStr |
Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015 |
title_full_unstemmed |
Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015 |
title_sort |
analysis of the literature and patents on solid dispersions from 1980 to 2015 |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2018-07-01 |
description |
Background: Solid dispersions are an effective formulation technique to improve the solubility, dissolution rate, and bioavailability of water-insoluble drugs for oral delivery. In the last 15 years, increased attention was focused on this technology. There were 23 marketed drugs prepared by solid dispersion techniques. Objective: This study aimed to report the big picture of solid dispersion research from 1980 to 2015. Method: Scientific knowledge mapping tools were used for the qualitative and the quantitative analysis of patents and literature from the time and space dimensions. Results: Western Europe and North America were the major research areas in this field with frequent international cooperation. Moreover, there was a close collaboration between universities and industries, while research collaboration in Asia mainly existed between universities. The model drugs, main excipients, preparation technologies, characterization approaches and the mechanism involved in the formulation of solid dispersions were analyzed via the keyword burst and co-citation cluster techniques. Integrated experimental, theoretical and computational tools were useful techniques for in silico formulation design of the solid dispersions. Conclusions: Our research provided the qualitative and the quantitative analysis of patents and literature of solid dispersions in the last three decades. |
topic |
solid dispersion big data literature patent scientific knowledge mapping CiteSpace |
url |
http://www.mdpi.com/1420-3049/23/7/1697 |
work_keys_str_mv |
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