Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

Lipid droplets are organelles that regulate lipid metabolism but if organellar contacts play a role during lipolysis is unclear. Here, the authors show that peroxisomes and peroxisomal protein PEX5 play pivotal roles in the spatial and temporal regulation of fasting-induced lipolysis by translocatin...

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Main Authors: Jinuk Kong, Yul Ji, Yong Geun Jeon, Ji Seul Han, Kyung Hee Han, Jung Hyun Lee, Gung Lee, Hagoon Jang, Sung Sik Choe, Myriam Baes, Jae Bum Kim
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14176-0
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spelling doaj-ca6fe38e928249d98547a91aacc29c512021-05-11T08:48:26ZengNature Publishing GroupNature Communications2041-17232020-01-0111111610.1038/s41467-019-14176-0Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5Jinuk Kong0Yul Ji1Yong Geun Jeon2Ji Seul Han3Kyung Hee Han4Jung Hyun Lee5Gung Lee6Hagoon Jang7Sung Sik Choe8Myriam Baes9Jae Bum Kim10National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National UniversityNational Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National UniversityNational Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National UniversityNational Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National UniversityNational Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National UniversityNational Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National UniversityNational Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National UniversityNational Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National UniversityNational Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National UniversityLaboratory of Cell Metabolism, Department of Pharmaceutical and Pharmacological Sciences, KU LeuvenNational Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National UniversityLipid droplets are organelles that regulate lipid metabolism but if organellar contacts play a role during lipolysis is unclear. Here, the authors show that peroxisomes and peroxisomal protein PEX5 play pivotal roles in the spatial and temporal regulation of fasting-induced lipolysis by translocating ATGL onto lipid dropletshttps://doi.org/10.1038/s41467-019-14176-0
collection DOAJ
language English
format Article
sources DOAJ
author Jinuk Kong
Yul Ji
Yong Geun Jeon
Ji Seul Han
Kyung Hee Han
Jung Hyun Lee
Gung Lee
Hagoon Jang
Sung Sik Choe
Myriam Baes
Jae Bum Kim
spellingShingle Jinuk Kong
Yul Ji
Yong Geun Jeon
Ji Seul Han
Kyung Hee Han
Jung Hyun Lee
Gung Lee
Hagoon Jang
Sung Sik Choe
Myriam Baes
Jae Bum Kim
Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
Nature Communications
author_facet Jinuk Kong
Yul Ji
Yong Geun Jeon
Ji Seul Han
Kyung Hee Han
Jung Hyun Lee
Gung Lee
Hagoon Jang
Sung Sik Choe
Myriam Baes
Jae Bum Kim
author_sort Jinuk Kong
title Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
title_short Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
title_full Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
title_fullStr Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
title_full_unstemmed Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
title_sort spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via pex5
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-01-01
description Lipid droplets are organelles that regulate lipid metabolism but if organellar contacts play a role during lipolysis is unclear. Here, the authors show that peroxisomes and peroxisomal protein PEX5 play pivotal roles in the spatial and temporal regulation of fasting-induced lipolysis by translocating ATGL onto lipid droplets
url https://doi.org/10.1038/s41467-019-14176-0
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AT yulji spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT yonggeunjeon spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT jiseulhan spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT kyungheehan spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT junghyunlee spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT gunglee spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT hagoonjang spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT sungsikchoe spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT myriambaes spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT jaebumkim spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
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