Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats
Background. Stress and its consequences are among the causes of accidents. Objective. The effects of intraventral tegmental area (I-VTA) memantine on the plasma corticosterone and eating parameters disturbance induced by acute stress were investigated. Methods. Male Wistar rats (W: 250–300 g) were d...
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Series: | Behavioural Neurology |
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doaj-ca7d2207258b412784a76c9a6555f0ab2021-07-02T09:35:24ZengHindawi LimitedBehavioural Neurology0953-41801875-85842014-01-01201410.1155/2014/294149294149Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in RatsZohreh Sadat Nasihatkon0Maryam Khosravi1Zahra Bourbour2Hedayat Sahraei3Mina Ranjbaran4Seyedeh Maryam Hassantash5Mohammad Sahraei6Kefayat Baghlani7Department of Biology, Faculty of Biological Science, North Tehran Branch, Islamic Azad University, Tehran 19395-6558, IranDepartment of Biology, Faculty of Biological Science, North Tehran Branch, Islamic Azad University, Tehran 19395-6558, IranNeuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran 19395-6558, IranNeuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran 19395-6558, IranNeuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran 19395-6558, IranNeuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran 19395-6558, IranFaculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran 19395-6558, IranDepartment of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah (a.s.) University of Medical Sciences, Tehran 19395-6558, IranBackground. Stress and its consequences are among the causes of accidents. Objective. The effects of intraventral tegmental area (I-VTA) memantine on the plasma corticosterone and eating parameters disturbance induced by acute stress were investigated. Methods. Male Wistar rats (W: 250–300 g) were divided into control and experiential groups, each of which received memantine either intra-VTA or peripherally. One week after bilateral cannulation, the rats received memantine (1 and 5 μg/Rat) five min before electroshock stress. The other experimental groups received memantine (1 and 5 mg/kg) intraperitoneally 30 min before stress. The control groups received saline or memantine but did not experience stress. Food and water intake and plasma corticosterone level were recorded. Results. Results showed that stress decreases food intake but does not change water intake and increase in plasma corticosterone level. Intraperitoneal memantine administration slightly inhibits the stress effects on food intake. However, water intake and plasma corticosterone level were increased. Intra-VTA memantine reduces the effects of stress on corticosterone and water intake. Conclusion. It could be concluded that inhibition of glutamate NMDA receptors in the VTA by memantine leads to the inhibition of the eating behavior parameters and plasma corticosterone level disturbance induced by stress in rats.http://dx.doi.org/10.1155/2014/294149 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zohreh Sadat Nasihatkon Maryam Khosravi Zahra Bourbour Hedayat Sahraei Mina Ranjbaran Seyedeh Maryam Hassantash Mohammad Sahraei Kefayat Baghlani |
spellingShingle |
Zohreh Sadat Nasihatkon Maryam Khosravi Zahra Bourbour Hedayat Sahraei Mina Ranjbaran Seyedeh Maryam Hassantash Mohammad Sahraei Kefayat Baghlani Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats Behavioural Neurology |
author_facet |
Zohreh Sadat Nasihatkon Maryam Khosravi Zahra Bourbour Hedayat Sahraei Mina Ranjbaran Seyedeh Maryam Hassantash Mohammad Sahraei Kefayat Baghlani |
author_sort |
Zohreh Sadat Nasihatkon |
title |
Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats |
title_short |
Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats |
title_full |
Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats |
title_fullStr |
Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats |
title_full_unstemmed |
Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats |
title_sort |
inhibitory effect of nmda receptors in the ventral tegmental area on hormonal and eating behavior responses to stress in rats |
publisher |
Hindawi Limited |
series |
Behavioural Neurology |
issn |
0953-4180 1875-8584 |
publishDate |
2014-01-01 |
description |
Background. Stress and its consequences are among the causes of accidents. Objective. The effects of intraventral tegmental area (I-VTA) memantine on the plasma corticosterone and eating parameters disturbance induced by acute stress were investigated. Methods. Male Wistar rats (W: 250–300 g) were divided into control and experiential groups, each of which received memantine either intra-VTA or peripherally. One week after bilateral cannulation, the rats received memantine (1 and 5 μg/Rat) five min before electroshock stress. The other experimental groups received memantine (1 and 5 mg/kg) intraperitoneally 30 min before stress. The control groups received saline or memantine but did not experience stress. Food and water intake and plasma corticosterone level were recorded. Results. Results showed that stress decreases food intake but does not change water intake and increase in plasma corticosterone level. Intraperitoneal memantine administration slightly inhibits the stress effects on food intake. However, water intake and plasma corticosterone level were increased. Intra-VTA memantine reduces the effects of stress on corticosterone and water intake. Conclusion. It could be concluded that inhibition of glutamate NMDA receptors in the VTA by memantine leads to the inhibition of the eating behavior parameters and plasma corticosterone level disturbance induced by stress in rats. |
url |
http://dx.doi.org/10.1155/2014/294149 |
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