MTHFR C677T genetic polymorphism in combination with serum vitamin B2, B12 and aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and esophageal precancerous lesions: a case–control study

MTHFR C677T genetic polymorphism in combination with serum vitamin B2, B12 and aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and esophageal precancerous lesions: a case–control study

Abstract Background The study aimed to explore the associations between the interactions of serum vitamin B2 or B12 levels, aberrant DNA methylation of p16 or p53 and MTHFR C677T polymorphism and the risks of esophageal squamous cell carcinoma (ESCC) and esophageal precancerous lesion (EPL). Methods...

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Bibliographic Details
Main Authors: Da Pan, Ming Su, Guiling Huang, Pengfei Luo, Ting Zhang, Lingmeng Fu, Jie Wei, Shaokang Wang, Guiju Sun
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cancer Cell International
Subjects:
Esophageal squamous cell carcinoma
Esophageal precancerous lesion
Methylenetetrahydrofolate reductase
Vitamin B2
Vitamin B12
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s12935-019-1012-x

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http://link.springer.com/article/10.1186/s12935-019-1012-x

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