Esquizofrenia, genética, epigênesis, ambiente: uma revisão sistemática das hipóteses etiológicas unificadas e do perfil genética; e um novo algoritmo para o tratamento dos achados principais
CContext: schizophrenia is a highly complex syndrome, related to genes, and to non-genetic risk factors. Famous epidemiological studies reported its presence among all cultures and geographic regions. In that sense, Unified Etiological hypothesis face the challenge to both present experimental data,...
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doaj-ca86aab060df4abfa83f857e7dcda82b2020-11-24T23:39:22ZengUniversidad del RosarioAvances en Psicología Latinoamericana1794-47242010-01-012812941Esquizofrenia, genética, epigênesis, ambiente: uma revisão sistemática das hipóteses etiológicas unificadas e do perfil genética; e um novo algoritmo para o tratamento dos achados principaisAvelino Luiz RodriguesÁlvaro Machado DiasCContext: schizophrenia is a highly complex syndrome, related to genes, and to non-genetic risk factors. Famous epidemiological studies reported its presence among all cultures and geographic regions. In that sense, Unified Etiological hypothesis face the challenge to both present experimental data, and to show that the findings may cope with the syndrome’s universal profi le. Objectives: systematically review the most prominent Unified Etiological hypothesis, as much as the semantic distribution of genetic findings (under up to date data mining techniques), and propose a new model, based on the dynamic effects of epigenics over genetic activation in both neurodevelopment and early adulthood. Results: in general, Unified Etiological Hypothesis contradict the main genetic findings (which suggest that schizophrenias’ genes are mostly associated with neurotransmitter profiles, like D-1 and the Glutamate-NMDA cascade); also in general, genetic findings are spread all over the genome (as we reveal with a topological map of the 3519 studies on the matter). The key for this conundrum may be represented by the association between the perspective that each polymorphism associated with schizophrenia represents a statistical risk factor (e.g. increasing the risk of developmental instability) while epigenetic molecular cascades and environmental factors considerably influence this picture, affecting genetic activation within critical periodshttp://revistas.urosario.edu.co/index.php/apl/article/view/1333/1196schizophreniaetiologybrain |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Avelino Luiz Rodrigues Álvaro Machado Dias |
spellingShingle |
Avelino Luiz Rodrigues Álvaro Machado Dias Esquizofrenia, genética, epigênesis, ambiente: uma revisão sistemática das hipóteses etiológicas unificadas e do perfil genética; e um novo algoritmo para o tratamento dos achados principais Avances en Psicología Latinoamericana schizophrenia etiology brain |
author_facet |
Avelino Luiz Rodrigues Álvaro Machado Dias |
author_sort |
Avelino Luiz Rodrigues |
title |
Esquizofrenia, genética, epigênesis, ambiente: uma revisão sistemática das hipóteses etiológicas unificadas e do perfil genética; e um novo algoritmo para o tratamento dos achados principais |
title_short |
Esquizofrenia, genética, epigênesis, ambiente: uma revisão sistemática das hipóteses etiológicas unificadas e do perfil genética; e um novo algoritmo para o tratamento dos achados principais |
title_full |
Esquizofrenia, genética, epigênesis, ambiente: uma revisão sistemática das hipóteses etiológicas unificadas e do perfil genética; e um novo algoritmo para o tratamento dos achados principais |
title_fullStr |
Esquizofrenia, genética, epigênesis, ambiente: uma revisão sistemática das hipóteses etiológicas unificadas e do perfil genética; e um novo algoritmo para o tratamento dos achados principais |
title_full_unstemmed |
Esquizofrenia, genética, epigênesis, ambiente: uma revisão sistemática das hipóteses etiológicas unificadas e do perfil genética; e um novo algoritmo para o tratamento dos achados principais |
title_sort |
esquizofrenia, genética, epigênesis, ambiente: uma revisão sistemática das hipóteses etiológicas unificadas e do perfil genética; e um novo algoritmo para o tratamento dos achados principais |
publisher |
Universidad del Rosario |
series |
Avances en Psicología Latinoamericana |
issn |
1794-4724 |
publishDate |
2010-01-01 |
description |
CContext: schizophrenia is a highly complex syndrome, related to genes, and to non-genetic risk factors. Famous epidemiological studies reported its presence among all cultures and geographic regions. In that sense, Unified Etiological hypothesis face the challenge to both present experimental data, and to show that the findings may cope with the syndrome’s universal profi le. Objectives: systematically review the most prominent Unified Etiological hypothesis, as much as the semantic distribution of genetic findings (under up to date data mining techniques), and propose a new model, based on the dynamic effects of epigenics over genetic activation in both neurodevelopment and early adulthood. Results: in general, Unified Etiological Hypothesis contradict the main genetic findings (which suggest that schizophrenias’ genes are mostly associated with neurotransmitter profiles, like D-1 and the Glutamate-NMDA cascade); also in general, genetic findings are spread all over the genome (as we reveal with a topological map of the 3519 studies on the matter). The key for this conundrum may be represented by the association between the perspective that each polymorphism associated with schizophrenia represents a statistical risk factor (e.g. increasing the risk of developmental instability) while epigenetic molecular cascades and environmental factors considerably influence this picture, affecting genetic activation within critical periods |
topic |
schizophrenia etiology brain |
url |
http://revistas.urosario.edu.co/index.php/apl/article/view/1333/1196 |
work_keys_str_mv |
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