Low-Molecular Weight Polyethylenimine Modified with Pluronic 123 and RGD- or Chimeric RGD-NLS Peptide: Characteristics and Transfection Efficacy of Their Complexes with Plasmid DNA
To solve the problem of transfection efficiency vs. cytotoxicity and tumor-targeting ability when polyethylenimine (PEI) was used as a nonviral gene delivery vector, new degradable PEI polymers were synthesized via cross-linking low-molecular-weight PEI with Pluronic P123 and then further coupled wi...
Main Authors: | Jing Hu, Wenfang Zhao, Kehai Liu, Qian Yu, Yuan Mao, Zeyu Lu, Yaguang Zhang, Manman Zhu |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2016-05-01
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Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/21/5/655 |
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