Excitotoxic glutamate causes neuronal insulin resistance by inhibiting insulin receptor/Akt/mTOR pathway
Abstract Aim An impaired biological response to insulin in the brain, known as central insulin resistance, was identified during stroke and traumatic brain injury, for which glutamate excitotoxicity is a common pathogenic factor. The exact molecular link between excitotoxicity and central insulin re...
Main Authors: | Igor Pomytkin, Irina Krasil’nikova, Zanda Bakaeva, Alexander Surin, Vsevolod Pinelis |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-12-01
|
Series: | Molecular Brain |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13041-019-0533-5 |
Similar Items
-
Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity
by: Irina Krasil’nikova, et al.
Published: (2019-09-01) -
Brain Insulin Resistance: Focus on Insulin Receptor-Mitochondria Interactions
by: Igor Pomytkin, et al.
Published: (2021-03-01) -
Glutamate transporters and excitotoxicity in nervous system
by: Shahraki A (PhD), et al.
Published: (2011-09-01) -
Ivermectin Protects against Monosodium Glutamate-Induced Excitotoxicity in the Rat
by: Arise Rotimi O., et al.
Published: (2019-03-01) -
Glutamate is an essential mediator in glutamine‐amplified insulin secretion
by: Guirong Han, et al.
Published: (2021-06-01)