Recent Advances in Cryo-TEM Imaging of Soft Lipid Nanoparticles
Cryo-transmission electron microscopy (Cryo-TEM), and its technological variations thereof, have become a powerful tool for detailed morphological characterization and 3D tomography of soft lipid and polymeric nanoparticles as well as biological materials such as viruses and DNA without chemical fix...
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AIMS Press
2015-05-01
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| Series: | AIMS Biophysics |
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| Online Access: | http://www.aimspress.com/biophysics/article/283/fulltext.html |
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doaj-cab6b7feaeb74820846eea0c9e80eee42020-11-25T01:15:34ZengAIMS PressAIMS Biophysics2377-90982015-05-012211613010.3934/biophy.2015.2.116201502116Recent Advances in Cryo-TEM Imaging of Soft Lipid NanoparticlesShen Helvig0Intan D. M. Azmi1Seyed M. Moghimi2Anan Yaghmur3Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2,2100 Copenhagen Ø, DenmarkDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2,2100 Copenhagen Ø, DenmarkNanomedicine Laboratory, Center for Pharmaceutical Nanotechnology and Nanotoxicology, Department of Pharmacy, University of Copenhagen, DK-2100 Copenhagen Ø, DenmarDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2,2100 Copenhagen Ø, DenmarkCryo-transmission electron microscopy (Cryo-TEM), and its technological variations thereof, have become a powerful tool for detailed morphological characterization and 3D tomography of soft lipid and polymeric nanoparticles as well as biological materials such as viruses and DNA without chemical fixation. Here, we review and discuss recent advances in Cryo-TEM analysis of lipid-based drug nanocarriers with particular emphasis on morphological and internal nanostructure characterization of lyotropic liquid crystalline nanoparticles such as cubosomes and hexosomes.http://www.aimspress.com/biophysics/article/283/fulltext.htmlcryo-TEMcubosomes3D tomographyhexosomesnanocarriers |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Shen Helvig Intan D. M. Azmi Seyed M. Moghimi Anan Yaghmur |
| spellingShingle |
Shen Helvig Intan D. M. Azmi Seyed M. Moghimi Anan Yaghmur Recent Advances in Cryo-TEM Imaging of Soft Lipid Nanoparticles AIMS Biophysics cryo-TEM cubosomes 3D tomography hexosomes nanocarriers |
| author_facet |
Shen Helvig Intan D. M. Azmi Seyed M. Moghimi Anan Yaghmur |
| author_sort |
Shen Helvig |
| title |
Recent Advances in Cryo-TEM Imaging of Soft Lipid Nanoparticles |
| title_short |
Recent Advances in Cryo-TEM Imaging of Soft Lipid Nanoparticles |
| title_full |
Recent Advances in Cryo-TEM Imaging of Soft Lipid Nanoparticles |
| title_fullStr |
Recent Advances in Cryo-TEM Imaging of Soft Lipid Nanoparticles |
| title_full_unstemmed |
Recent Advances in Cryo-TEM Imaging of Soft Lipid Nanoparticles |
| title_sort |
recent advances in cryo-tem imaging of soft lipid nanoparticles |
| publisher |
AIMS Press |
| series |
AIMS Biophysics |
| issn |
2377-9098 |
| publishDate |
2015-05-01 |
| description |
Cryo-transmission electron microscopy (Cryo-TEM), and its technological variations thereof, have become a powerful tool for detailed morphological characterization and 3D tomography of soft lipid and polymeric nanoparticles as well as biological materials such as viruses and DNA without chemical fixation. Here, we review and discuss recent advances in Cryo-TEM analysis of lipid-based drug nanocarriers with particular emphasis on morphological and internal nanostructure characterization of lyotropic liquid crystalline nanoparticles such as cubosomes and hexosomes. |
| topic |
cryo-TEM cubosomes 3D tomography hexosomes nanocarriers |
| url |
http://www.aimspress.com/biophysics/article/283/fulltext.html |
| work_keys_str_mv |
AT shenhelvig recentadvancesincryotemimagingofsoftlipidnanoparticles AT intandmazmi recentadvancesincryotemimagingofsoftlipidnanoparticles AT seyedmmoghimi recentadvancesincryotemimagingofsoftlipidnanoparticles AT ananyaghmur recentadvancesincryotemimagingofsoftlipidnanoparticles |
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