Autism Spectrum Disorder and Neonatal Serum Magnesium Levels in Preterm Infants
Premature birth is associated with increased risk of autism spectrum disorder. Antenatal maternal magnesium administration is known to reduce subsequent risk of cerebral palsy including among premature infants, suggesting a potentially broader neuroprotective role for magnesium. Our objective was to...
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2018-09-01
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Series: | Child Neurology Open |
Online Access: | https://doi.org/10.1177/2329048X18800566 |
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doaj-cab9c163254e4b22bd4bde0a901e257a2020-11-25T04:02:52ZengSAGE PublishingChild Neurology Open2329-048X2018-09-01510.1177/2329048X18800566Autism Spectrum Disorder and Neonatal Serum Magnesium Levels in Preterm InfantsAmanda V. Bakian PhD0Deborah A. Bilder MD1E. Kent Korgenski MS2Joshua L. Bonkowsky MD, PhD3 Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA Intermountain Healthcare, Salt Lake City, UT, USA Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USAPremature birth is associated with increased risk of autism spectrum disorder. Antenatal maternal magnesium administration is known to reduce subsequent risk of cerebral palsy including among premature infants, suggesting a potentially broader neuroprotective role for magnesium. Our objective was to determine whether magnesium could be protective against autism spectrum disorders in premature infants. A cohort of 4855 preterm children was identified, magnesium levels from 24 to 48 hours of life recorded, and subsequent autism spectrum disorder status determined. Adjusted relative risk of autism spectrum disorder with each 1 mg/dL increase in neonatal magnesium level was 1.15 (95% confidence interval: 0.86-1.53). Analysis of variance indicated that magnesium levels varied by gestational age and maternal antenatal magnesium supplementation, but not autism spectrum disorder status ( F 1,4824 = 1.43, P = .23). We found that neonatal magnesium levels were not associated with decreased autism spectrum disorder risk. Future research into autism spectrum disorder risks and treatments in premature infants is needed.https://doi.org/10.1177/2329048X18800566 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amanda V. Bakian PhD Deborah A. Bilder MD E. Kent Korgenski MS Joshua L. Bonkowsky MD, PhD |
spellingShingle |
Amanda V. Bakian PhD Deborah A. Bilder MD E. Kent Korgenski MS Joshua L. Bonkowsky MD, PhD Autism Spectrum Disorder and Neonatal Serum Magnesium Levels in Preterm Infants Child Neurology Open |
author_facet |
Amanda V. Bakian PhD Deborah A. Bilder MD E. Kent Korgenski MS Joshua L. Bonkowsky MD, PhD |
author_sort |
Amanda V. Bakian PhD |
title |
Autism Spectrum Disorder and Neonatal Serum Magnesium Levels in Preterm Infants |
title_short |
Autism Spectrum Disorder and Neonatal Serum Magnesium Levels in Preterm Infants |
title_full |
Autism Spectrum Disorder and Neonatal Serum Magnesium Levels in Preterm Infants |
title_fullStr |
Autism Spectrum Disorder and Neonatal Serum Magnesium Levels in Preterm Infants |
title_full_unstemmed |
Autism Spectrum Disorder and Neonatal Serum Magnesium Levels in Preterm Infants |
title_sort |
autism spectrum disorder and neonatal serum magnesium levels in preterm infants |
publisher |
SAGE Publishing |
series |
Child Neurology Open |
issn |
2329-048X |
publishDate |
2018-09-01 |
description |
Premature birth is associated with increased risk of autism spectrum disorder. Antenatal maternal magnesium administration is known to reduce subsequent risk of cerebral palsy including among premature infants, suggesting a potentially broader neuroprotective role for magnesium. Our objective was to determine whether magnesium could be protective against autism spectrum disorders in premature infants. A cohort of 4855 preterm children was identified, magnesium levels from 24 to 48 hours of life recorded, and subsequent autism spectrum disorder status determined. Adjusted relative risk of autism spectrum disorder with each 1 mg/dL increase in neonatal magnesium level was 1.15 (95% confidence interval: 0.86-1.53). Analysis of variance indicated that magnesium levels varied by gestational age and maternal antenatal magnesium supplementation, but not autism spectrum disorder status ( F 1,4824 = 1.43, P = .23). We found that neonatal magnesium levels were not associated with decreased autism spectrum disorder risk. Future research into autism spectrum disorder risks and treatments in premature infants is needed. |
url |
https://doi.org/10.1177/2329048X18800566 |
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