Screening of Apiaceae fruits discovered natural resources with considerable biological potential
Background: Apiaceae fruits as common spices used for prevention of many chronic diseases including cancer. Objective: The present study compared the biological effects of different fruits from various Apiaceae tribes to compare and find the fraction source(s) with potential characteristics for furt...
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2020-11-01
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doaj-cabcf9624a154b43884b09e5b527eff02021-09-19T04:17:02ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582020-11-0119764658Screening of Apiaceae fruits discovered natural resources with considerable biological potentialZahra Tofighi0Mostafa Pirali Hamedani1Saeed Tavakoli2Mir Javad Tabatabaei3Marzieh Rabei4Shamim Mohtadi5Farnoosh Mirghaffari6Maryam Afshani7Farhad Kahrizi8Behruz Khodabandeloo9Saeede Jafari-Nodooshan10Mahdieh Shirzad11Elahe Motevaseli12Saied Goodarzi13 Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran International Campus, ICTUMS, Tehran University of Medical Sciences, Tehran, Iran 1Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Background: Apiaceae fruits as common spices used for prevention of many chronic diseases including cancer. Objective: The present study compared the biological effects of different fruits from various Apiaceae tribes to compare and find the fraction source(s) with potential characteristics for further investigation including cancer prevention. Methods: Fruits of Apium graveolens L. (celery), Bunium persicum (Boiss.) B.Fedtsch. (black cumin), Petroselinum crispum (Mill.) Fuss (parsley), Pimpinella anisum L. (anise), Trachyspermum ammi (L.) Sprague (ajwain), Coriandrum sativum L. (coriander), Foeniculum vulgare Mill. (fennel), Anethum graveolens L. (dill), Heracleum persicum Desf. ex Fisch., C.A.Mey. & Avé-Lall. (Persian hogweed), Ferula assa-foetida L. (asafoetida), Cuminum cyminum L. (cumin) and Daucus carota L. (carrot) were extracted with 80 % methanol and fractionated by petroleum ether, chloroform, ethyl acetate and methanol, respectively. For different fractions and total extract of all 12 samples, cytotoxicity by brine shrimp test (BST) and MTT assay against cancer and normal cell (foreskin fibroblast cells), antioxidant effects by FRAP, and total phenols by Folin-Ciocalteu method were measured. Results: The general toxicity of ethyl acetate fractions (mean of data) was higher than others in the brine shrimp test (P < 0.05). The most cytotoxic fractions against colon carcinoma (HT-29), breast adenocarcinoma (MDA-MB-231) and alveolar basal epithelial adenocarcinoma (A549) cell lines were from Ammineae and Peucedaneae tribes while fruits fractions with high phenol contents and antioxidant powers were from Ammineae tribe. Conclusion: The Apiaceae fruits have significant biological effects, therefore the isolation of phytochemical compounds from active fractions with cytotoxicity is suggested in future studies.http://jmp.ir/article-1-2657-en.htmlumbelliferaefruitscytotoxicreducing powerphenol content |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zahra Tofighi Mostafa Pirali Hamedani Saeed Tavakoli Mir Javad Tabatabaei Marzieh Rabei Shamim Mohtadi Farnoosh Mirghaffari Maryam Afshani Farhad Kahrizi Behruz Khodabandeloo Saeede Jafari-Nodooshan Mahdieh Shirzad Elahe Motevaseli Saied Goodarzi |
spellingShingle |
Zahra Tofighi Mostafa Pirali Hamedani Saeed Tavakoli Mir Javad Tabatabaei Marzieh Rabei Shamim Mohtadi Farnoosh Mirghaffari Maryam Afshani Farhad Kahrizi Behruz Khodabandeloo Saeede Jafari-Nodooshan Mahdieh Shirzad Elahe Motevaseli Saied Goodarzi Screening of Apiaceae fruits discovered natural resources with considerable biological potential Journal of Medicinal Plants umbelliferae fruits cytotoxic reducing power phenol content |
author_facet |
Zahra Tofighi Mostafa Pirali Hamedani Saeed Tavakoli Mir Javad Tabatabaei Marzieh Rabei Shamim Mohtadi Farnoosh Mirghaffari Maryam Afshani Farhad Kahrizi Behruz Khodabandeloo Saeede Jafari-Nodooshan Mahdieh Shirzad Elahe Motevaseli Saied Goodarzi |
author_sort |
Zahra Tofighi |
title |
Screening of Apiaceae fruits discovered natural resources with considerable biological potential |
title_short |
Screening of Apiaceae fruits discovered natural resources with considerable biological potential |
title_full |
Screening of Apiaceae fruits discovered natural resources with considerable biological potential |
title_fullStr |
Screening of Apiaceae fruits discovered natural resources with considerable biological potential |
title_full_unstemmed |
Screening of Apiaceae fruits discovered natural resources with considerable biological potential |
title_sort |
screening of apiaceae fruits discovered natural resources with considerable biological potential |
publisher |
Institue of Medicinal Plants, ACECR |
series |
Journal of Medicinal Plants |
issn |
2717-204X 2717-2058 |
publishDate |
2020-11-01 |
description |
Background: Apiaceae fruits as common spices used for prevention of many chronic diseases including cancer. Objective: The present study compared the biological effects of different fruits from various Apiaceae tribes to compare and find the fraction source(s) with potential characteristics for further investigation including cancer prevention. Methods: Fruits of Apium graveolens L. (celery), Bunium persicum (Boiss.) B.Fedtsch. (black cumin), Petroselinum crispum (Mill.) Fuss (parsley), Pimpinella anisum L. (anise), Trachyspermum ammi (L.) Sprague (ajwain), Coriandrum sativum L. (coriander), Foeniculum vulgare Mill. (fennel), Anethum graveolens L. (dill), Heracleum persicum Desf. ex Fisch., C.A.Mey. & Avé-Lall. (Persian hogweed), Ferula assa-foetida L. (asafoetida), Cuminum cyminum L. (cumin) and Daucus carota L. (carrot) were extracted with 80 % methanol and fractionated by petroleum ether, chloroform, ethyl acetate and methanol, respectively. For different fractions and total extract of all 12 samples, cytotoxicity by brine shrimp test (BST) and MTT assay against cancer and normal cell (foreskin fibroblast cells), antioxidant effects by FRAP, and total phenols by Folin-Ciocalteu method were measured. Results: The general toxicity of ethyl acetate fractions (mean of data) was higher than others in the brine shrimp test (P < 0.05). The most cytotoxic fractions against colon carcinoma (HT-29), breast adenocarcinoma (MDA-MB-231) and alveolar basal epithelial adenocarcinoma (A549) cell lines were from Ammineae and Peucedaneae tribes while fruits fractions with high phenol contents and antioxidant powers were from Ammineae tribe. Conclusion: The Apiaceae fruits have significant biological effects, therefore the isolation of phytochemical compounds from active fractions with cytotoxicity is suggested in future studies. |
topic |
umbelliferae fruits cytotoxic reducing power phenol content |
url |
http://jmp.ir/article-1-2657-en.html |
work_keys_str_mv |
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