Targeting cellular metabolism using rapamycin and/or doxycycline enhances anti-tumour effects in human glioma cells

Targeting cellular metabolism using rapamycin and/or doxycycline enhances anti-tumour effects in human glioma cells

Abstract Background Glioma is the most common highly aggressive, primary adult brain tumour. Clinical data show that therapeutic approaches cannot reach the expectations in patients, thus gliomas are mainly incurable diseases. Tumour cells can adapt rapidly to alterations during therapeutic treatmen...

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Bibliographic Details
Main Authors: Gábor Petővári, Zoltán Hujber, Ildikó Krencz, Titanilla Dankó, Noémi Nagy, Fanni Tóth, Regina Raffay, Katalin Mészáros, Hajnalka Rajnai, Enikő Vetlényi, Krisztina Takács-Vellai, András Jeney, Anna Sebestyén
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Cancer Cell International
Subjects:
Glioblastoma
mTOR inhibitor
Anti-metabolic drug combinations
Tumour metabolism
Rapamycin
Doxycycline
Online Access:http://link.springer.com/article/10.1186/s12935-018-0710-0

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