Combined therapy with adipose tissue-derived mesenchymal stromal cells and meglumine antimoniate controls lesion development and parasite load in murine cutaneous leishmaniasis caused by Leishmania amazonensis

Combined therapy with adipose tissue-derived mesenchymal stromal cells and meglumine antimoniate controls lesion development and parasite load in murine cutaneous leishmaniasis caused by Leishmania amazonensis

Abstract Background Leishmaniasis is a neglected disease caused by Leishmania spp. One of its characteristics is an imbalance of host immune responses to foster parasite survival. In this setting, mesenchymal stromal cells (MSCs) may be a viable therapeutic alternative, given their well-established...

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Main Authors: Tadeu Diniz Ramos, Johnatas Dutra Silva, Alessandra Marcia da Fonseca-Martins, Juliana Elena da Silveira Pratti, Luan Firmino-Cruz, Diogo Maciel-Oliveira, Julio Souza Dos-Santos, João Ivo Nunes Tenorio, Almair Ferreira de Araujo, Célio Geraldo Freire-de-Lima, Bruno Lourenço Diaz, Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco, Herbert Leonel de Matos Guedes
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Stem Cell Research & Therapy
Subjects:
Leishmaniasis
Mesenchymal stromal cells
Adipose tissue-derived mesenchymal stromal cells
Meglumine antimoniate
Bone marrow-derived mesenchymal stromal cells
Parasite load
Online Access:http://link.springer.com/article/10.1186/s13287-020-01889-z

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