Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation.
Mortality due to Covid-19 is highly associated with advanced age, owing in large part to severe lower respiratory tract infection. SARS-CoV-2 utilizes the host ACE2 receptor for infection. Whether ACE2 abundance in the lung contributes to age-associated vulnerability is currently unknown. We set out...
Main Authors: | Steven Andrew Baker, Shirley Kwok, Gerald J Berry, Thomas J Montine |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0247060 |
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